Produção Nacional
Revisado por pares
Antiulcerogenic activity of the extracts of Struthanthus marginatus
2011; Springer Science+Business Media; Volume: 21; Issue: 6 Linguagem: Inglês
10.1590/s0102-695x2011005000150
ISSN1981-528X
AutoresSonia Freire, Karla N. de S. Andrade, Gilvan A. Aragão, Elda Pereira Noronha, Selma do N. Silva, Maria do Socorro de S. Cartágenes, Marilene Oliveira da Rocha Borges, Maria Nilce de Sousa Ribeiro, Luce Maria Brandão Torres, Antônio Carlos Romão Borges,
Tópico(s)Botanical Research and Applications
ResumoThe gastroprotective action of the aqueous extract (AE) and the hydroalcoholic extract obtained from the leaves of Struthanthus marginatus (Desr.) Blume, Loranthaceae, were performed with in vivo models in rodents using: ethanol, indomethacin or stress-induced ulcers, determination of gastric secretion and the mucus production. The scavenger activity of AE in vitro was tested by the DPPH method. The treatment with the extracts (125-1000 mg/kg) significantly inhibited ulcerative lesions in comparison with the negative control groups in all the models evaluated and demonstrated greater effectiveness of the aqueous extract. Regarding the model of gastric secretion, a reduction in volume of gastric juice and total acidity was observed, as well as an increase in the gastric pH. The treatment of rats raised the gastric mucus production. Significant DPPH scavenging activity was evident in the AE. No sign of toxicity was observed. These results show that S. marginatus possesses gastroprotective activity. There are indications that the mechanisms involved in anti-ulcer activity are related to a decrease in acid secretion and an increase in gastric mucus content. Also, there is evidence for the involvement of antioxidant activity in the gastroprotective mechanism.
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