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Investigating the association of chemokine receptor 5 (CCR5) polymorphism with cervical cancer in human papillomavirus (HPV) positive patients

2008; UNIVERSIDADE ESTADUAL DE MARINGÁ; Volume: 30; Issue: 2 Linguagem: Inglês

10.4025/actascihealthsci.v30i2.944

1807-8648

Maria Angélica Ehara Watanabe, Patrícia Sayuri Suzuki, Karen Brajão de Oliveira, Mateus Nóbrega Aoki, Vera Lúcia Hideko Tatakihara, Sueli Donizete Borelli,

Chemokine receptors and signaling

HPV is the most responsible of cervical cancer. It is known that chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) gene is involved in the chemotaxis of leukocytes toward inflammation sites. In the present study, polymerase chain reactions (PCR) in genomic DNA samples, using specific CCR5 oligonucleotide primers surrounding the breakpoint deletion, detected a 225bp product from the normal CCR5 allele and a 193bp product from the 32bp deletion allele. The wild type genotype was prevalent in both group, but it wasn’t statistically significant with χ² =1,519 (2 degrees of freedom; p>0.05). Once there is a small number of 32 allele carriers, further studies are needed to clarify the role of CCR5 in the cervical cancer.