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Interleukin‐12 as Vaccine Adjuvant

1996; Wiley; Volume: 795; Issue: 1 Linguagem: Holandês

10.1111/j.1749-6632.1996.tb52652.x

1749-6632

J L Bliss, RICHARD MAYLOR, KEYA STOKES, KRISTIN S. MURRAY, M Ketchum, Stanley F. Wolf,

Immune Cell Function and Interaction

Annals of the New York Academy of SciencesVolume 795, Issue 1 p. 26-35 Interleukin-12 as Vaccine Adjuvant Characteristics of Primary, Recall, and Long-Term Responses JUDY BLISS, JUDY BLISS Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorRICHARD MAYLOR, RICHARD MAYLOR Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorKEYA STOKES, KEYA STOKES Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorKRISTIN S. MURRAY, KRISTIN S. MURRAY Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorMARA A. KETCHUM, MARA A. KETCHUM Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorSTANLEY F. WOLF, Corresponding Author STANLEY F. WOLFAddress for correspondence and reprint requests: Dr. S. F. Wolf, Genetics Institute Inc., Preclinical Molecular and Cellular Biology, One Burtt Road, Andover, MA 01810.Search for more papers by this author JUDY BLISS, JUDY BLISS Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorRICHARD MAYLOR, RICHARD MAYLOR Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorKEYA STOKES, KEYA STOKES Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorKRISTIN S. MURRAY, KRISTIN S. MURRAY Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorMARA A. KETCHUM, MARA A. KETCHUM Genetics Institute Inc., Preclinical Molecular and Cellular Biology, Cambridge, Massachusetts 02140Search for more papers by this authorSTANLEY F. WOLF, Corresponding Author STANLEY F. WOLFAddress for correspondence and reprint requests: Dr. S. F. Wolf, Genetics Institute Inc., Preclinical Molecular and Cellular Biology, One Burtt Road, Andover, MA 01810.Search for more papers by this author First published: October 1996 https://doi.org/10.1111/j.1749-6632.1996.tb52652.xCitations: 17AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Trinchieri, G. 1994. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells Type 1 and cytotoxic lymphocytes. Blood 84: 4008–4027. 2 Trinchieri, G. 1995. Interleukin-12: A pro-inflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Ann. Rev. Immunol. 13: 251–276. 3 Hsieh, C.-S., S. E. Macatonia, C. S. Tripp, S. F. Wolf, A. O'Garra & K. M. Murphy. 1993. Development of TH1 CD4+ T cells through IL12 produced by Listeria-induced macrophages. Science 260: 547–549. 4 Macatonia, S. E., N. A. Hosken, M. Litton, P. Vieira, C. S. Hsieh, J. A. Culpepper, M. Wysocka, G. Trinchieri, K. M. Murphy & A. O'Garra. 1995. Dendritic cells produce IL-12 and direct the development of Thl cells from naive CD4+ T cells. J. Immunol. 154: 5071–5079. 5 Hsieh, C.-S., S. E. Macatonia, A. O'Garra & K. M. Murphy. 1995. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181: 713–721. 6 Mosmann, T. R. & R. L. Coffman. 1989. Thl and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol. 7: 145. 7 Afonso, L. C. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri & P. Scott. 1994. The adjuvant effect of IL-12 in a vaccine against Leishmania major. Science 263: 235–236. 8 McKnight, A. J., G. J. Zimmer, I. Fogelman, S. F. Wolf & A. K. Abbas. 1994. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152: 2172–2179. 9 Bliss, J., V. VanCleave, K. Murray, A. Wiencis, M. Ketchum, R. Maylor, T. Haire, C. Resmini, A. K. Abbas & S. Wolf. 1996. Interleukin 12 as an adjuvant, promotes a T helper 1 but does not suppress a T helper 2 recall response. J. Immunol. 156: 887–894. 10 Buchanan, J. M., L. A. Vogel, V. H. VanCleave & D. W. Metzger. 1995. Interleukin-12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme. Intl. Immunol. 7: 1519–1528. 11 Murphy, B. E., K. Shibuya, N. Hosken, P. Openshaw, V. Maino, K. Davis, K. Murphy & A. O'Garra. 1996. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183: 901–913. Citing Literature Volume795, Issue1Interleukin 12: Cellular and Molecular Immunology of an Important Regulatory CytokineOctober 1996Pages 26-35 ReferencesRelatedInformation