Neuroactive Substances in Cerebrospinal Fluid
1988; Wiley; Volume: 531; Issue: 1 Linguagem: Romeno
10.1111/j.1749-6632.1988.tb31808.x
ISSN1749-6632
AutoresRobert M. Post, David R. Rubinow, Mitchel A. Kling, Wade H. Berrettini, Philip W. Gold,
Tópico(s)Alcoholism and Thiamine Deficiency
ResumoAnnals of the New York Academy of SciencesVolume 531, Issue 1 p. 15-28 Neuroactive Substances in Cerebrospinal Fluid Normal and Pathological Regulatory Mechanisms† ROBERT M. POST, ROBERT M. POST National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this authorDAVID R. RUBINOW, DAVID R. RUBINOW National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this authorMITCHEL A. KLING, MITCHEL A. KLING National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this authorWADE BERRETTINI, WADE BERRETTINI National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this authorPHILIP W. GOLD, PHILIP W. GOLD National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this author ROBERT M. POST, ROBERT M. POST National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this authorDAVID R. RUBINOW, DAVID R. RUBINOW National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this authorMITCHEL A. KLING, MITCHEL A. KLING National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this authorWADE BERRETTINI, WADE BERRETTINI National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this authorPHILIP W. GOLD, PHILIP W. GOLD National Institute of Mental Health Bethesda, Maryland 20892Search for more papers by this author First published: June 1988 https://doi.org/10.1111/j.1749-6632.1988.tb31808.xCitations: 8 †Address correspondence to: Robert M. Post, M.D., Chief, Biological Psychiatry Branch, NIMH, Bldg 10, Room 3N212, 9000 Rockville Pike, Bethesda, Maryland 20892. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Hosobuchi, Y., J. Rossier, F. E. Bloom & R. Guillemin. 1978. Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid. Science 203: 279–283. 2 Akil, H., D. E. Richardson, J. D. Barchas & C. H. Li. 1978. Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation. Proc. Natl. Acad. Sci. USA 75: 5170–5172. 3 Akil, H., D. E. Richardson, J. Hughes & J. Barchas. 1978. Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation. Science 201: 463–465. 4 Tari, A., Y. Miyachi, K. Tanaka, A. Miyoshi, Y. Mayanagi & A. Mizuchi. 1983. Elevated immunoreactive beta-endorphin level in ventricular fluid after analgesic electrical stimulation of posteromedial hypothalamus. Endocrinol. Jpn. 30: 747–752. 5 Fessler, R. G., F. D. Brown, J. R. Rachlin, S. Mullan & V. S. Fang. 1984. Elevated beta-endorphin in cerebrospinal fluid after electrical brain stimulation: artifact of contrast infusion? Science 224: 1017–1019. 6 Wood, J. H. 1983. Physiology and pharmacology of peptide, steroid, and other hormones in cerebrospinal fluid. In Neurobiology of Cerebrospinal Fluid 2. J. H. Wood, Ed. 43–65. Plenum Press. New York , NY. 7 Post, R. M., P. W. Gold, D. R. Rubinow, W. E. Bunney, Jr., J. C. Ballenger & F. K. Goodwin. 1983. Cerebrospinal fluid as neuroregulatory pathway: CSF peptides in neuropsychiatric illness. In Neurobiology of Cerebrospinal Fluid 2. J. H. Wood, Ed. 107–141. Plenum Press. New York , NY. 8 Reppert, S. M., H. G. Artman, S. Swaminathan & D. A. Fisher. 1981. Vasopressin exhibits a rhythmic daily pattern in cerebrospinal fluid but not in blood. Science 213: 1256–1257. 9 Garrick, N. A., J. L. Hill, F. G. Szele, T. P. Tomai, P. W. Gold & D. L. Murphy. 1987. Corticotropin releasing hormone: a marked circadian rhythm in primate cerebrospinal fluid peaks in the evening and is inversely related to the cortisol circadian rhythm. Endocrinology 121: 1329–1334. 10 Kalin, N. H. & W. T. McKinney. 1986. Diurnal rhythm of CRH concentration in primate CSF. In Abstracts, American College of Neuropsychopharmacology (ACNP) 25th Annual Meeting, Washington, DC, Dec. 812, 1986, p. 170. 11 Knigge, K. M., C. Bennett-Clarke, B. Burchanowski, S. A. Joseph, M. A. Romagnamo & L. A. Sternberger. 1980. Relationships of some releasing-hormone-producing neuron systems to the ventricles of the brain. In Endocrine Functions of the Brain. M. Motta, Ed. 195–206. Raven Press. New York , NY. 12 Forssmann, W. G. 1978. A new somatostatinergic system in the mammalian spinal cord. Neurosci. Lett. 10: 293–297. 13 Sheppard, M., S. Kronheim, C. Adams & B. Pimstone. 1979. Immunoreactive somatostatin release from rat spinal cord in vitro. Neurosci. Lett. 15: 65–70. 14 Weindl, A., J. Triepel & G. Kuchling. 1984. Somatostatin in the brain of the turtle “testudo hermanni” gmelinAn immunohistochemical mapping study. Peptides 5:(1): 91–100. 15 Herkenham, M. & S. McLean. 1986. Mismatches between receptor and transmitter localization in the brain. In Neurology and Neurobiology: Quantitative Receptor Autoradiography. C. A. Boast, E. W. Snowhill & C. A. Alter, Eds. Vol. 19: 137–171. Alan R. Liss, Inc. New York , NY. 16 Post, R. M., P. W. Gold, D. R. Rubinow, J. C. Ballenger, W. E. Bunney, Jr. & F. K. Goodwin. 1982. Peptides in the cerebrospinal fluid of neuropsychiatric patients: an approach to central nervous system peptide function. Life Sci. 31: 1–15. 17 Wood, J. H. 1983. Physiology and pharmacology of peptide, steroid, and other hormones in cerebrospinal fluid. In Neurobiology of Cerebrospinal Fluid 2. J. H. Wood, Ed. 43–65. Plenum Press. New York , NY. 18 Ziegler, M. G., C. R. Lake, J. H. Wood & M. H. Ebert. 1983. Norepinephrine in cerebrospinal fluid: basic studies, effects of drugs and disease. In Neurobiology of Cerebrospinal Fluid 2. J. H. Wood, Ed. 141–152. Plenum Press. New York , NY. 19 Hosobuchi, Y. & F. E. Bloom. 1983. Analgesia induced by brain stimulation in man: its effect on release of beta-endorphin and adrenocorticotropin into cerebrospinal fluid. In Neurobiology of Cerebrospinal Fluid 2. J. H. Wood, Ed. 97–105. Plenum Press. New York , NY. 20 Hokfelt, T., B. Everitt, V. R. Holets, B. Meister, T. Melander, M. Schalling, W. Staines & J. M. Lundberg. 1986. Coexistence of peptides and other active molecules in neurons: diversity of chemical signalling potential. In Fast and Slow Chemical Signalling in the Nervous System. L. L. Iversen & E. Goodman, Eds. 205–231. Oxford University Press. New York , NY. 21 Leah, J. D., A. A. Cameron, W. L. Kelly & P. J. Snow. 1985. Coexistence of peptide immunoreactivity in sensory neurons of the cat. Neuroscience 16: 683–690. 22 Phillips, A. G. 1987. Interaction between mesolimbic dopamine neurons, cholecystokinin and neurotensin: evidence using in vivo voltammetry. In Abstracts, N.Y. Academy of Science Conference on the Mesocorticolimbic Dopamine System, Miami, FL, May 46, 1987, Session V/27. 23 Berrettini, W. H., J. I. Nurnberger, Jr., P. W. Gold, M. Chretien, G. P. Chrousos, J. S. Chan, L. R. Goldin & E. S. Gershon. 1985. Neuropeptides in human cerebrospinal fluid. Life Sci. 37: 1265–1270. 24 Kaye, W. H., D. R. Rubinow, H. Gwirtsman, D. P. George, D. C. Jimerson & P. W. Gold. 1987. CSF somatostatin in anorexia nervosa and bulimia: relationship to the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology. In press. 25 Sunderland, T., D. R. Rubinow, P. N. Tariot, R. M. Cohen, P. A. Newhouse, A. M. Mellow, E. A. Mueller & D. L. Murphy. 1987. CSF somatostatin in patients with Alzheimer's disease, older depressed patients and age-matched control subjects. Am. J. Psychiatry 144: 1313–1316. 26 Berrettini, W. H., J. I. Nurnberger, J. Gelernter, S. Simmons-Alling & O. Wolkowitz. 1987. Studies of human CSF neuropeptides. New Research Abstracts of the American Psychiatric Assoc. 140th Annual Meeting, Chicago, IL, May 914, 1987, p. 37, NR30. 27 Rubinow, D. R., P. W. Gold, R. M. Post, J. C. Ballenger, R. Cowdry, J. Bollinger & S. Reichlin. 1983. Somatostatin in affective illness. Arch. Gen. Psychiatry 40: 403–412. 28 Rubinow, D. R. 1986. Cerebrospinal fluid somatostatin and psychiatric illness. Biol. Psychiatry 21: 341–365. 29 Sorensen, K. V., S. E. Christensen, E. Dupont, A. P. Hansen, E. Pedersen & H. Orskov. 1980. Low somatostatin content in cerebrospinal fluid in multiple sclerosis. Acta Neurol. Scand. 61: 186–191. 30 Beal, M. F., M. F. Mazurek, P. McL. Black & J. B. Martin. 1985. Human cerebrospinal somatostatin in neurologic disease. J. Neurol. Sci. 71: 91–104. 31 Oram, J. J., J. Edwardson & P. H. Millard. 1981. Investigation of cerebrospinal fluid neuropeptides in idiopathic senile dementia. Gerontology 27: 216–223. 32 Wood, P. L., P. Etienne, S. Lal, S. Gauthier, S. Cajal & N. P. V. Nair. 1982. Reduced lumbar CSF somatostatin in Alzheimer's disease. Life Sci. 31: 2073–2079. 33 Serby, M., S. B. Richardson, S. Twente, J. Siekierski, J. Corwin & J. Rotrosen. 1984. CSF somatostatin in Alzheimer's disease. Neurobiol. Aging 5: 187–189. 34 Soininen, H. S., J. T. Jolkkonen, K. J. Reinikainen, T. O. Halonen & P. J. Riekkinen. 1984. Reduced cholinesterase activity and somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with dementia of the Alzheimer type. J. Neurol. Sci. 63: 167–172. 35 Raskind, M. A., E. R. Peskind, T. H. Lampe, S. C. Risse, G. J. Taborsky, Jr. & D. Dorsa. 1986. Cerebrospinal fluid vasopressin, oxytocin, somatostatin, and betaendorphin in Alzheimer's disease. Arch. Gen. Psychiatry 43: 382–388. 36 Tamminga, C. A., N. L. Foster, P. Fedio, E. D. Bird & T. N. Chase. 1987. Alzheimer's disease: low cerebral somatostatin levels correlate with impaired cognitive function and cortical metabolism. Neurology 37: 161–165. 37 Kuraishi, Y., N. Hirota, Y. Sato, Y. Hino, M. Satoh & H. Takagi. 1985. Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn. Brain Res. 325: 294–298. 38 Reinikainen, K. J., P. J. Riekkinen, J. Jolkkonen, V.-M. Kosma & H. Soininen. 1987. Decreased somatostatin-like immunoreactivity in cerebral cortex and cerebrospinal fluid in Alzheimer's disease. Brain Res. 402: 103–108. 39 Morrison, J. H., J. Rogers, S. Scherr, R. Benoit & F. E. Bloom. 1985. Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients. Nature 314: 90–92. 40 Roberts, G. W., T. J. Crow & J. M. Polak. 1985. Localization of neuronal tangles in somatostatin neurones in Alzheimer's disease. Nature 314: 92–94. 41 Perry, E. K. & R. H. Perry. 1982. Neurotransmitter and neuropeptide systems in Alzheimer-type dementia. Exp. Brain Res. 140: 140–145. 42 Kulmala, H. K. & J. T. Hutton. 1985. Role of the senile plaque in neuropeptide deficits in Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 9: 625–628. 43 Orskov, H., A. P. Hansen, B., De Fine Olivarius, E. Pedersen, K. Sorensen, E. Dupont, J. Ingerslev & S. E. Christensen. 1981. Cerebrospinal fluid (CSF) somatostatin like immunoreactivity (SLI). Methodology: secretion and origin, and pathology in neurological disease. In Proceedings, 3rd World Congress of Biological Psychiatry. C. Perris, G. Struew & B. Jansson, Eds. Elsevier, Amsterdam . 44 Dupont, E., S. E. Christensen, A. P. Hansen, B., De Fine Olivarius & H. Orskov. 1982. Low cerbrospinal fluid somatostatin in Parkinson's disease: an irreversible abnormality. Neurology 32: 312–314. 45 Jolkkonen, J., H. Soininen, T. Halonen, A. Ylinen, V. Laulumaa, M. Laakso & P. Riekkinen. 1986. Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia. J. Neurol. Neurosurg. Psychiatry 49: 1374–1377. 46 Sorensen, K. V. 1987. Somatostatin in multiple sclerosis. Acta Neurol. Scand. 75: 161–167. 47 Kling, M. A., G. P. Chrousos, A. Roy, A. R. Doran, J. R. Calabrese & P. W. Gold. 1986. CSF CRH and ACTH in depression and Cushing's disease. In Abstracts, 139th Annual Meeting, American Psychiatric Assoc., Washington, DC, 1986, p. 75, abstract #27B. 48 Vecsei, L., I. Bollok & G. Telegdy. 1983. Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats. Peptides 4: 293–295. 49 Vecsei, L., C. Kiraly, I. Bollok, A. Nagy, J. Varga, B. Penke & G. Telegdy. 1984. Comparative studies with somatostatin and cysteamine in different behavior tests on rats. Pharmacol. Biochem. Behav. 21: 833–837. 50 Walsh, T. J., D. F. Emrich, A. Winocus, C. Banki, G. Bissette & C. B. Nemeroff. 1985. Intrahippocampal injection of cysteamine depletes somatostatin and produces cognitive impairments in the rat. In Abstracts, Society for Neuroscience 15th Annual Meeting, Dallas, Texas, Oct. 2025, 1985, p. 621, abstract #182.7. 51 Reisine, T. 1985. Multiple mechanisms of somatostatin inhibition of adrenocorticotropin release from mouse anterior pituitary tumor cells. Endocrinology 116: 2259–2266. 52 Brown, M., L. Fisher, J. Spiess, et al. 1982. Corticotropin releasing factor: effects on the sympathetic nervous system (SNS), vasopressin release, and cardiovascular regulation (abstract 581). In Proceedings of the 64th Annual Meeting of the Endocrine Society, 1982, p. 225. 53 Doran, A. R., D. R. Rubinow, A. Roy & D. Pickar. 1986. CSF somatostatin and abnormal response to dexamethasone administration in schizophrenic and depressed patients. Arch. Gen. Psychiatry 43: 365–369. 54 Agren, H. & G. Lundqvist. 1984. Low levels of somatostatin in human CSF mark depressive episodes. Psychoneuroendocrinology 9: 233–248. 55 Bissette, G., E. Widerlov, H. Walleus, I. Karlsson, K. Eklund, A. Forsman & C. B. Nemeroff. 1986. Alterations in cerebrospinal fluid concentrations of somatostatin-like immunoreactivity in neuropsychiatric disorders. Arch. Gen. Psychiatry 43: 1148–1151. 56 Wolkowitz, O. M., D. R. Rubinow, A. Breier, A. R. Doran, C. Davis & D. Pickar. 1987. Prednisone decreases CSF somatostatin in healthy humans: implications for neuropsychiatric illness. Life Sci. In press. 57 Kellner, C. H., Y. Davenport, R. M. Post & R. J. Ross. 1984. Rapidly cycling bipolar disorder and multiple sclerosis. Am. J. Psychiatry 141: 112–113. 58 Joffe, R. T., G. P. Lippert, T. A. Gray, G. Sawa & Z. Horvath. 1987. Mood disorder and multiple sclerosis. Arch. Neurol. 44: 376–378. 59 Kato, N., T. Higuchi, H. G. Friesen & J. A. Wada. 1983. Changes of immunoreactive somatostatin and beta-endorphin content in rat brain after amygdala kindling. Life Sci. 32: 2415–2422. 60 Higuchi, T., G. S. Sikand, N. Kato, J. A. Wada & H. G. Friesen. 1983. Profound suppression of kindled seizures by cysteamine: possible role of somatostatin in kindled seizures. Brain Res. 288: 359–362. 61 Assouline, G., E. Barkaie & J. Gutnik. 1984. Cysteamine suppresses kindled seizures in pentylenetetrazol-kindled rats. Eur. J. Pharmacol. 106: 649–652. 62 Rubinow, D. R., R. M. Post, P. W. Gold, J. C. Ballenger & S. Reichlin. 1985. Effects of carbamazepine on cerebrospinal fluid somatostatin. Psychopharmacology 85: 210–213. 63 Steardo, L., P. Barone & E. Hunnicutt. 1986. Carbamazepine lowering effect on CSF somatostatin-like immunoreactivity in temporal lobe epileptics. Acta Neurol. Scand. 74: 140–144. 64 Higuchi, T., N. Kato, T. Noguchi, H. G. Friesen & J. A. Wada. 1987. Kindling and somatostatin. In J. A. Wada Kindling, Ed. 349–360. Raven Press. New York , NY. 65 Nagaki, S., N. Kato, Y. Minatogawa & T. Higuchi. 1986. Effects of anticonvulsants on immunoreactive somatostatin and gamma-aminobutyric acid contents in the rat brain. Epilepsia 27: 639. 66 Weiss, S. R. B., T. Nguyen, D. R. Rubinow, C. J. Helke, P. K. Narang, R. M. Post & D. M. Jacobowitz. 1987. Lack of effect of chronic carbamazepine on brain somatostatin in the rat. J. Neural Transm. 68: 325–333. 67 Gold, P. W., D. L. Loriaux, A. Roy, M. A. Kling, J. R. Calabrese, C. H. Kellner, L. K. Nieman, R. M. Post, D. Pickar & W. Gallucci. 1986. Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's diseasePathophysiologic and diagnostic implications. N. Engl. J. Med. 314: 1329–1335. 68 Davis, K., B. Davis, R. Mohns, et al. 1984. CSF corticotropin releasing factor in neuropsychiatric diseases. In New Research Abstracts, 137th Annual Meeting of the American Psychiatric Assoc., Washington, DC, 1984. 69 Roy, A., D. Pickar, S. Paul, A. Doran, G. P. Chrousos & P. W. Gold. 1987. CSF corticotropin-releasing hormone in depressed patients and normal control subjects. Am. J. Psychiatry 144: 641–645. 70 Nemeroff, C. B., E. Widerlov, G. Bissette, H. Walleus, I. Karlsson, K. Eklund, C. D. Kilts, P. T. Loosen & W. Vale. 1984. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226: 1342–1344. 71 Nemeroff, C. 1986. TRH and neurotensin during stress and psychiatric disease. Presented at the NIH Conference on Mechanisms of Physical and Emotional Stress, Bethesda, MD, Nov. 68, 1986. 72 Mouradian, M. M., J. M. Farah, E. Mohr, G. Fabbrini, T. L. O'Donohue & T. N. Chase. 1986. Spinal fluid CRF reduction in Alzheimer's disease. Neuropeptides 8: 393–400. 73 May, C., S. I. Rapoport, T. P. Tomai, G. P. Chrousos & P. W. Gold. 1987. Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH) and corticotropin (ACTH) are reduced in patients with Alzheimer's disease. Neurology 37: 535–538. 74 Lumpkin, M. D., W. K. Samson & S. M. McCann. 1987. Arginine vasopressin as a thyrotropin-releasing hormone. Science 235: 1070–1073. 75 Nemeroff, C. B. & J. Simon. 1987. Abnormal thyroid function in psychiatric patients. In Abstracts, American Psychiatric Assoc. 140th Annual Meeting, Chicago, May 914, 1987, Symposium #77-D, p. 119. 76 Reichlin, S. 1987. Regulation of hypothalamic-pituitary axis. 15th Annual Solomon A. Berson Memorial Lecture, NIMH, Bethesda, MD, May 29, 1987. 77 Post, R. M., K. G. Kramlinger, R. T. Joffe, P. W. Gold & T. W. Uhde. 1987. Effects of carbamazepine on thyroid function. In Abstracts, American Psychiatric Assoc. 140th Annual Meeting, Chicago, May 914, 1987, Symposium #104-D, p. 142. 78 Extein, I., A. L. C. Pottash, M. S. Gold & R. W. Cowdry. 1984. Changes in TSH response to TRH in affective illness. In Neurobiology of Mood Disorders. R. M. Post & J. C. Ballenger, Eds. 297–310. Williams & Wilkins. Baltimore , MD . 79 Joffe, R. T., P. P. Roy-Byrne, T. W. Uhde & R. M. Post. 1984. Thyroid function and affective illness: a reappraisal. Biol. Psychiatry 19: 1685–1691. 80 Kalin, N. H. 1985. Behavioral effects of ovine corticotropin-releasing factor administered to rhesus monkeys. Fed. Proc. 1(2): 249–253. 81 Ehlers, C. L., S. J. Henriksen, M. Wang, J. Rivier, W. Vale & F. E. Bloom. 1983. Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Res. 278: 332–336. 82 Koob, G. F. 1985. Stress, corticotropin releasing factor and behavior. In Perspectives in Behavioral Medicine, Neuroendocrine Control and Behavior. R. B. Williams, Ed. Academic Press. New York , NY. 83 Weiss, S. R. B., R. M. Post, P. W. Gold, C. Chrousos, T. L. Sullivan, D. Walker & A. Pert. 1986. CRF-induced seizures and behavior: interaction with amygdala kindling. Brain Res. 372: 345–351. 84 Meynadier, J., J. Chrubasik, M. Dubar & E. Wunsch. 1985. Intrathecal somatostatin in terminally ill patientsA report of two cases. Pain 23: 9–12. 85 Chrubasik, J. 1985. Somatostatin. A review. Anasth. Intensivther. Notfallmed. 20: 165–170. 86 Cutler, N. R., J. V. Haxby, P. K. Narang, C. May, C. Burg & S. A. Reines. 1985. Evaluation of an analogue of somatostatin (L363,586) in Alzheimer's disease [letter]. N. Engl. J. Med. 312: 725. 87 Gerner, R. H. & T. Yamada. 1982. Altered neuropeptide concentrations in CSF of psychiatric patients. Brain Res. 238: 298–302. 88 Black, P., Mc L., T. Ballantine, Jr., D. B. Carr, M. F. Beal & J. B. Martin. 1986. beta-Endorphin and somatostatin concentrations in the ventricular cerebrospinal fluid of patients with affective disorder. Biol. Psychiatry 21: 1077–1081. Citing Literature Volume531, Issue1Neurological Applications of Implanted Drug PumpsJune 1988Pages 15-28 ReferencesRelatedInformation
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