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Identification of H-type BSE in Portugal

2015; Landes Bioscience; Volume: 9; Issue: 1 Linguagem: Inglês

10.1080/19336896.2014.997615

1933-690X

Leonor Orge, Carla Guedes Machado, Luísa Ramalho, Renata Carvalho, João S. Silva, Paula Almeida, Paula Tavares, Cristina Ochôa, Carla Caroline Valença de Lima, M. J. Pinto, J. Pedro Simas,

RNA regulation and disease

During the bovine spongiform encephalopathy (BSE) epidemic, Portugal was the third most affected country. As a result of a successful national eradication plan, the number of BSE affected animals has been progressively declining in Portugal with no cases identified in 2013. However, within the scope of this active surveillance scheme, we have identified the first H-type BSE case born after the introduction of the reinforced ban in fallen stock. Here, we report the phenotypic features of this case and the analysis of the protein coding sequence of prnp as well as the prnp promoter and intron 1 insertion-deletions.