CT1341: some effects in man
1971; Wiley; Volume: 26; Issue: 4 Linguagem: Inglês
10.1111/j.1365-2044.1971.tb04814.x
ISSN1365-2044
AutoresT.M. Savege, Eleanor I. Foley, R. J. Coultas, B Walton, L. Strunin, B. R. Simpson, D. F. Scott,
Tópico(s)Anesthesia and Sedative Agents
ResumoAnaesthesiaVolume 26, Issue 4 p. 402-413 Free Access CT1341: some effects in man Cardiorespiratory, electroencephalographic and biochemical measurements T. M. Savege, T. M. Savege T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorEleanor I. Foley, Eleanor I. Foley T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorR. J. Coultas, R. J. Coultas T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorB. Walton, B. Walton T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorL. Strunin, L. Strunin T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorB. R. Simpson, B. R. Simpson T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorD. F. Scott, D. F. Scott T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this author T. M. Savege, T. M. Savege T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorEleanor I. Foley, Eleanor I. Foley T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorR. J. Coultas, R. J. Coultas T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorB. Walton, B. Walton T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorL. Strunin, L. Strunin T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorB. R. Simpson, B. R. Simpson T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this authorD. F. Scott, D. F. Scott T. M. Savege, MB, BS, FFARCS, Senior Lecturer; Eleanor I. Foley, MB, BS, FFARCS, Lecturer; R. J. Coultas, MB, BS, FFARCS, Lecturer; B. Walton, MB, BS, FFARCS, Lecturer; L. Strunin, MB, BS, FFARCS, Assistant Director; B. R. Simpson, D.Phil, FFARCS, Professor, Anaesthetics Unit and D. F. Scott, MRCP, DPM, Consultant in Charge of the Electroencephalography Department; the London Hospital, White chapel, London El IBB. Technical assistance was given by J. M. Strunin, BSc, J. M. Layton, BSc, M. P. Maxwell, ASCT, NZ Cert Sci and M. Sulley. Dr R.J. Coultas is at present Senior Registrar Anaesthetist at the Royal Victoria Infirmary, Newcastle upon Tyne. Requests for reprints should be sent to Dr Savege, Anaesthetics Unit, London Hospital, Whitechapel, London El IBB.Search for more papers by this author First published: October 1971 https://doi.org/10.1111/j.1365-2044.1971.tb04814.xCitations: 38AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Child, K. J., Currie, J. P., Davis, B., Dodds, M. G., Pearce, D. R. and Twissell, D. J. (1971). The pharmacological properties in animals of CT1341 - a new steroid anaesthetic agent. British Journal of Anaesthesia, 43, 2. 2 Campbell, D., Forrester, A. C, Miller, D. C, Hutton, I., Kennedy, J. A., Lawrie, T. D. V., Lorimer, A. R. and Mccall, D. (1971). A preliminary clinical study of CT1341 -a steroid anaesthetic agent. British Journal of Anaesthesia, 43, 14. 3 Montgomery, F. J., Clarke, R. S. J., Dundee, J. W. and Bovill, J. W. (1971). Clinical studies with a new steroid anaesthetic CT1341. Communication to the Anaesthetic Research Society, Belfast Meeting, March 26th, 1971. 4 Savege, T. M., Coultas, R. J., Walton, B., Howell, M. E. O., Scott, D. F., Strunin, L. and Simpson, B. R. (1971). Some effects of CT1341 in man. Communication to the Anaesthetic Research Society, Belfast Meeting, March 26th, 1971. 5 Folev, E. R., Walton, B., Savege, T. M., Strunin, L. and Simpson, B. R. A comparison of recovery times between methohexitone and CT1341 following anaesthesia for electroconvulsive therapy, (in preparation). 6 Maynard, D., Prior, P. F. and Scott, D. F. (1969). Device for continuous monitoring of cerebral activity in resuscitated patients. British Medical Journal, 4, 545. 7 Faulconer, A. and Bickford, R. G. (1960). Electroencephalography in anesthesiology p. 16. Springfield , Illinois : Thomas. 8 Sadove, M. S., Becka, D. and Gibbs, F. A. (1967). Electroencephalography for anaes-thesiologists and surgeons, p. 26. London : Pitman Medical. 9 Townsend, J. and James, V. H. T. (1968). Semi-automated fiuorimetric procedure for determination of plasma corticosteroids. Steroids, 11, 497. 10 Johnson, S. R. (1951). The effects of some anaesthetic agents on the circulation in man. Acta Chirurgica Scandinavica, Suppl. 158. 11 Etsten, B. and U, T. H. (1955). Haemodynamic changes during thiopental anesthesia in humans. 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(1965).In Pharmakologische Untersuchungen mit Propanidid. “Die intravenöse Kurznarkose mit dem neuen Phenoxyessigseäurederivat Propanidid”. Edited by K. Horatz, R. Frey and M. Zindler p. 22. Heidelberg : Springer-Verlag. 19 Savege, T. M., Foley, E. I., Scott, D. F., Strunin, L. and Simpson, B R. The cardiorespiratory and electroencephalographic effects of cremophor EL in man (in preparation). 20 Elder, I. D., Nagano, S. M., Eastwood, D. W. and Harnagel, D. (1965). Circulatory changes associated with thiopental anesthesia in man. Anesthesiology, 16, 394. 21 Prys-roberts, C, Kelman, G. R., Greenbaum, R., Kain, M. L. and Bay, J. (1968).Haemodynamic and alveolar-arterial PO2 differences at varying Paco2 in anes-thetised man. Journal of Applied Physiology, 25, 80. 22 Boyan, C. P., Howland, W. S. and Bellville, J. W. (1956). The electroencephalographic pattern during steroid narcosis. Current Researches in Anesthesia and Analgesia, 35, 415. Citing Literature Volume26, Issue4October 1971Pages 402-413 ReferencesRelatedInformation
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