Portal de Periódicos da CAPES

Revisão Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Understanding liver immunology using intravital microscopy

2015; Elsevier BV; Volume: 63; Issue: 3 Linguagem: Inglês

10.1016/j.jhep.2015.05.027

1600-0641

Pedro Elias Marques, A. G. de Oliveira, Lynne Chang, Heitor A. Paula-Neto, Gustavo Batista Menezes,

Immunotherapy and Immune Responses

The liver has come a long way since it was considered only a metabolic organ attached to the gastrointestinal tract. The simultaneous ascension of immunology and intravital microscopy evidenced the liver as a central axis in the immune system, controlling immune responses to local and systemic agents as well as disease tolerance. The multiple hepatic cell populations are organized in a vascular environment that promotes intimate cellular interactions, including initiation of innate and adaptive immune responses, rapid leukocyte recruitment, pathogen clearance and production of a variety of immune mediators. In this review, we focus on the advances in liver immunology supported by intravital microscopy in diseases such as isquemia/reperfusion, acute liver injury and infections.