Septic shock caused by Gram-positive bacteria**Septic Shock Caused by Gram-positive Bacteria, organized by James Cook and Giuseppe Teti, was held at Vibo Valentia, Italy, 10–12 October 1998.
1999; Elsevier BV; Volume: 7; Issue: 3 Linguagem: Inglês
10.1016/s0966-842x(99)01453-5
ISSN1878-4380
Autores Tópico(s)Sepsis Diagnosis and Treatment
ResumoThe incidence of sepsis and septic shock caused by Gram-positive bacteria has been increasing over the past two decades, whereas the incidence of Gram-negative sepsis has remained fairly constant. Consequently, between a third and a half of all cases of sepsis (∼2 per year per 1000 population) are currently caused by Gram-positive microorganisms. The clinical manifestations of septic shock are caused by the elevated release of inflammatory mediators and cytokines by host cells upon interaction with bacterial products. Gram-positive microorganisms do not contain lipopolysaccharide (LPS), which is mainly responsible for the initiation of Gram-negative shock. Relative to the many studies conducted with LPS, much less is known of bacterial initiators and the cell activation mechanisms involved in Gram-positive shock. This information is crucial to the development of alternative strategies aimed at reducing sepsis lethality, which is still high (∼35%) despite adequate therapy. The meeting in Vibo Valentia represents the first organized attempt to address these issues.
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