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Phosphoglucomutase Kinetics with the Phosphates of Fructose, Glucose, Mannose, Ribose, and Galactose

1969; Elsevier BV; Volume: 244; Issue: 4 Linguagem: Inglês

10.1016/s0021-9258(18)91872-7

1083-351X

O. H. Lowry, Janet V. Passonneau,

Pancreatic function and diabetes

Abstract Kinetic measurements have been made for phosphoglucomutase with fructose 1,6-diphosphate, fructose 1-phosphate, fructose 6-phosphate, glucose 1-phosphate, glucose 6-phosphate, mannose 1-phosphate, mannose 6-phosphate, ribose 1-phosphate, ribose 5-phosphate, galactose 1-phosphate, and galactose 6-phosphate. For the monophosphates of fructose and ribose, evidence is presented for a rate-limiting step within the central complex. The equilibrium ratio for mannose-6-P to mannose-1-P has been estimated to be 10, and that for α-glucose-6-P to β-glucose-6-P to be 0.7.