Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides
2015; Elsevier BV; Volume: 126; Issue: 4 Linguagem: Inglês
10.1182/blood-2014-11-611194
ISSN1528-0020
AutoresLaura Y. McGirt, Peilin Jia, Devin A. Baerenwald, Robert J. Duszynski, Kimberly B. Dahlman, John A. Zic, Jeffrey P. Zwerner, Donald Hucks, Utpal P. Davé, Zhongming Zhao, Christine M. Eischen,
Tópico(s)Chronic Lymphocytic Leukemia Research
ResumoKey Points High-throughput sequencing of MF revealed multiple mutations within epigenetic and cytokine pathways that may drive disease. Pharmacologically targeting the JAK3 pathway in MF results in cell death and may be an effective treatment of this disease.
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