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Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil

2015; Brazilian Academy of Sciences; Volume: 87; Issue: 2 suppl Linguagem: Inglês

10.1590/0001-3765201520150056

1678-2690

Gabriela Lima da Silva, Carolina Luft, Adroaldo Lunardelli, Robson Henrich Amaral, Denizar Alberto da Silva Melo, Márcio Vinı́cius Fagundes Donadio, Fernanda Bordignon Nunes, Marcos Schuch de Azambuja, João Carlos Batista Santana, Cristina Machado Bragança de Moraes, Ricardo Obalski de Mello, Eduardo Cassel, MARCOS AURÉLIO DE ALMEIDA PEREIRA, Jarbas Rodrigues de Oliveira,

Natural product bioactivities and synthesis

Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The inflammatory response evoked by carrageenan and by croton oil was reduced through the pre-treatment of animals with LEO. In the pleurisy model, the drug used as positive control, dexamethasone, was more efficacious. However, in the ear swelling, the antiedematogenic effect of the oil was similar to that observed for dexamethasone. In the formalin test, LEO consistently inhibited spontaneous nociception and presented a similar effect to that of tramadol. The results of this study reveal (in vivo) the analgesic and anti-inflammatory activities of LEO and demonstrates its important therapeutic potential.