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Bisphosphonates: Mechanisms of Action and Clinical Use

1993; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-77991-6_11

1865-0325

H. Fleisch,

Connective tissue disorders research

The bisphosphonates are a new class of drugs which have been developed in the past 2 decades for use in various diseases of bone, tooth, and calcium metabolism. This chapter will cover the chemistry, the mechanisms of action, and the clinical applications of these compounds. Since a review was published on the same topic in this handbook in 1988 (Fleisch 1988), some parts which were extensively discussed there will be kept short. Emphasis will be on newer developments and on clinical aspects. For complete information the reader should consult both articles.