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BIBTEX RIS

Distribution and proliferation of bone marrow cells in the brain after pilocarpine‐induced status epilepticus in mice

2010; Wiley; Volume: 51; Issue: 8 Linguagem: Inglês

10.1111/j.1528-1167.2010.02570.x

ISSN

1528-1167

Autores

Beatriz M. Longo, Simone Romariz, Miriam Marcela Blanco, Juliana Fraga Vasconcelos, Luciana Bahia, Milena Botelho Pereira Soares, Luiz E. Mello, Ricardo Ribeiro‐dos‐Santos,

Tópico(s)

Neuroscience and Neuropharmacology Research

Resumo

Summary The distribution of bone marrow cells in brain areas during the acute period after pilocarpine‐induced status epilepticus (SE) was investigated here. To achieve this, we generated chimeric mice by engrafting bone marrow cells from enhanced green fluorescent protein (eGFP) transgenic mice. GFP + bone marrow–derived cells were found throughout the brain, predominantly in the hippocampus. As expected, these cells exhibited the characteristics of microglia. The pattern of distribution, proliferation, and differentiation of GFP + cells changes as a function of intensity and time following SE. This pattern is also a consequence of the inflammatory response, which is followed by the progressive neuronal damage that is characteristic of the pilocarpine model.

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