Angiogenic factors and ovarian follicle development
2009; Colégio Brasileiro de Patologia Animal (CBPA); Volume: 6; Issue: 2 Linguagem: Inglês
ISSN
1984-3143
AutoresJamily Bezerra Bruno, M.H.T. Matos, Roberta Nogueira Chaves, J.J.H. Celestino, M. V. A. Saraiva, I.B. Lima-Verde, Valdevane Rocha Araújo, J.R. Figueiredo,
Tópico(s)Endometriosis Research and Treatment
ResumoAbstract Ovarian follicles require an adequate blood supply for oxygen, nutrients and hormones, in addition to eliminating CO 2 and other metabolites. Acquisition of an adequate vascular supply is probably a limiting step in the selection and maturation of the dominant follicle. In this way, there is a progressive interest in the study of the growth factors involved in the angiogenic process. In addition, a better understanding about the mechanisms that regulate the expression and action of these factors could be a key point to increase the reproductive performance in females. Therefore, this review aims to summarize current data on the importance of the pro- and anti-angiogenic growth factors which regulate angiogenesis in ovarian follicle development. Keywords : angiogenesis, follicle, growth factors, ovary. Introduction During embryo development, blood vessels differentiate from endothelial precursors by a process called vasculogenesis. Angiogenesis is the process of new blood vessel development from pre-existing vasculature that occurs in embryos and adults (Stouffer
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