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Barrett's Dysplasia Cancer Task Force – Bad Cat: A Global, Multidisciplinary, Consensus on the Management of High Grade Dysplasia and Early Mucosal Cancer in Barrett's Esophagus

2011; Elsevier BV; Volume: 140; Issue: 5 Linguagem: Inglês

10.1016/s0016-5085(11)60721-x

1528-0012

Janusz Jankowski, Nimish Vakil, Mark K. Ferguson, Cathy Bennett, Paul Moayyedi, Jacques Bergman, Rebecca Harrison, Hugh Barr, John de Caestecker, John M. Inadomi, Nicholas J. Shaheen, Stephen J. Meltzer, M. Brian Fennerty, Irving Waxman, Krish Ragunath, Peter J. Kahrilas, Stephen E. Attwood, Michael Vieth, Laura J. Gay, Kausilia K. Krishnadath, Gaius Longcroft–Wheaton, Rajvinder Singh, David Armstrong, Kenneth K. Wang, Pradeep Bhandari, David Poller, Lisa Yerian, Michio Hongo, Elaine W. Kay, S. Sanders,

Gastric Cancer Management and Outcomes

by 35%.Conclusions: These data are consistent with the notion that 5ASA decreases Akt activation through multiple mechanisms regulating PTEN.We show that PTEN is affected by 5ASA-induced PPARγ activation as well as 5ASA-mediated inhibition of oxidation.Furthermore, PPARγ itself is involved in the antioxidant system and establishes an important role for the regulation of ROS by 5ASA in both cell signaling and gene expression.Taken together, we suggest these mechanisms have the potential to prevent β catenin S552 phosphorylation and therefore reduce PC activation.