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From Here to Eternity—The Theory and Practice of a Really Long Experiment

2015; Public Library of Science; Volume: 13; Issue: 6 Linguagem: Inglês

10.1371/journal.pbio.1002185

1545-7885

Jeremy W. Fox, Richard E. Lenski,

Gene Regulatory Network Analysis

In February 1988, Richard Lenski set up 12 replicate populations of a single genotype of Escherichia coli in a simple nutrient medium. He has been following their evolution ever since. Here, Lenski answers provocative questions from Jeremy Fox about his iconic "Long-Term Evolution Experiment" (LTEE). The LTEE is a remarkable case study of the interplay of determinism and chance in evolution-and in the conduct of science.