Portal de Periódicos da CAPES

Structure and Function of the Macrophage Mannose Receptor

2001; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-540-46410-5_6

1861-0412

Maureen E. Taylor,

Monoclonal and Polyclonal Antibodies Research

The mannose receptor acts as a molecular scavenger by mediating Ca2+-dependent recognition and internalization of glycoconjugates terminating in mannose, N-acetylglucosamine or fucose. The receptor was identified when it was found that glycoproteins terminating in GlcNAc or mannose, including lysosomal enzymes, are rapidly cleared from the bloodstream by the liver (Schlesinger et al. 1976). The mannose receptor was found to be located on hepatic endothelial cells and Kupffer cells but not on hepatocytes (Schlesinger et al. 1978). The receptor has since been found on most types of tissue macrophages, including those of the placenta, but not on circulating monocytes (Shepherd et al. 1982). The retinal pigmented epithelium, a phagocytic cell layer, also expresses the mannose receptor (Shepherd et al. 1991). More recently, the mannose receptor has been identified on CD1-positive dendritic cells and Langerhan's cells (Sallusto et al. 1995; Condaminet et al. 1998).