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Association analysis of the IL-1 gene cluster polymorphisms with aggressive and chronic periodontitis in the Algerian population

2015; Elsevier BV; Volume: 60; Issue: 10 Linguagem: Inglês

10.1016/j.archoralbio.2015.06.018

1879-1506

Kawther Nourelhouda Boukortt, Nadjia Saidi-Ouahrani, Boubaker Boukerzaza, Hadjira Ouhaïbi-Djellouli, Khalida Hachmaoui, Fatima Zohra Benaissa, Leila Taleb, Hayet Drabla-Ouahrani, Tahria Deba, Sid Ahmed Ouledhamou, Nadhera Mehtar, Abdallah Boudjema,

Streptococcal Infections and Treatments

There is strong evidence that genetic as well as environmental factors affect the development of periodontitis. Various studies suggest that genetic polymorphisms of the interleukin-1 (IL-1) genes are associated with an increased risk of developing the pathogenesis. The aim of the present study was to investigate the possible relationship between two polymorphisms of IL-1 gene cluster IL-1B (C + 3954T) (rs1143634) and IL-1A (C − 889T) (rs1800587) SNPs and the aggressive and chronic periodontitis risk in a case control study in Algerian population. 279 subjects were recruited and received a periodontal examination: 128 healthy controls and 151 cases. From cases, 91 patients were having a chronic disease whereas 60 subjects with aggressive form. All these subjects were genotyped for IL-1A (C − 889T) and IL-1B (C + 3954T) polymorphisms using TaqMan real time PCR technology. Frequencies of IL-1 alleles, genotypes and the haplotypes were also examined. Significant differences were found in the carriage rate of both minor alleles of the IL-1A (C − 889T) and IL-1B (C + 3954T) polymorphisms of aggressive periodontitis cases compared with healthy controls (OR [95%CI] = 1.61 [1.03–2.49], p = 0.03), (OR [95%CI] = 1.69 [1.09–2.63], p = 0.01), respectively. The result did not reach significance with the chronic form. The studied polymorphisms of the IL-1 genes appear to be associated with susceptibility to aggressive periodontitis (AgP) in the Algerian population.