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Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients.

1988; Springer Nature; Volume: 7; Issue: 9 Linguagem: Inglês

10.1002/j.1460-2075.1988.tb03134.x

1460-2075

D S Anson, Derek J. Blake, Peter R. Winship, Daniel Birnbaum, G.G. Brownlee,

Hemophilia Treatment and Research

Research Article1 September 1988free access Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients. D. S. Anson D. S. Anson Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author D. J. Blake D. J. Blake Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author P. R. Winship P. R. Winship Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author D. Birnbaum D. Birnbaum Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author G. G. Brownlee G. G. Brownlee Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author D. S. Anson D. S. Anson Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author D. J. Blake D. J. Blake Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author P. R. Winship P. R. Winship Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author D. Birnbaum D. Birnbaum Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author G. G. Brownlee G. G. Brownlee Sir William Dunn School of Pathology, University of Oxford, UK. Search for more papers by this author Author Information D. S. Anson1, D. J. Blake1, P. R. Winship1, D. Birnbaum1 and G. G. Brownlee1 1Sir William Dunn School of Pathology, University of Oxford, UK. The EMBO Journal (1988)7:2795-2799https://doi.org/10.1002/j.1460-2075.1988.tb03134.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The mcf.2 transforming gene sequence has been located to the region between 29 and 61 kb 3′ of the factor IX gene. Two unrelated haemophilia B patients who raise antibodies to infused factor IX ('inhibitors') have deletions in excess of 273 kb encompassing the factor IX and mcf.2 genes and a CG-rich island. We believe these patients show the first nullisomic deletion of a transforming gene to be reported. No clinical condition can be attributed to the loss of the mcf.2 gene. Previous ArticleNext Article Volume 7Issue 91 September 1988In this issue RelatedDetailsLoading ...