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P-selectin-mediated platelet adhesion promotes tumor growth

2015; Impact Journals LLC; Volume: 6; Issue: 9 Linguagem: Inglês

10.18632/oncotarget.3164

1949-2553

Cuiling Qi, Bo Wei, Weijie Zhou, Yang Yang, Bin Li, Simei Guo, Jialin Li, Jie Ye, Jiangchao Li, Qianqian Zhang, Tian Lan, Xiaodong He, Liu Cao, Jia Zhou, Jian‐Guo Geng, Lijing Wang,

Platelet Disorders and Treatments

// Cuiling Qi 1, * , Bo Wei 2, * , Weijie Zhou 3, * , Yang Yang 1 , Bin Li 1 , Simei Guo 1 , Jialin Li 1 , Jie Ye 1 , Jiangchao Li 1 , Qianqian Zhang 1 , Tian Lan 1 , Xiaodong He 1 , Liu Cao 4 , Jia Zhou 5 , Jianguo Geng 3 , Lijing Wang 1 1 Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China 2 Department of Gastrointestinal Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China 3 Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA 4 Key Laboratory of Medical Cell Biology, China Medical University, Shen Yang City, Liao Ning Province 110001, China 5 Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, USA * These authors have contributed equally to this work Correspondence to: Lijing Wang, e-mail: wanglijing62@163.com Keywords: P-selectin, platelets, tumor growth, αIIbβ3, talin1 Received: September 15, 2014 Accepted: January 19, 2015 Published: February 09, 2015 ABSTRACT Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the β3 cytoplasmic tail. This activates αIIbβ3 and recruits platelets into tumors. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism.