Endoscopic Treatment of Reflux: Migration of Teflon to the Lungs and Brain
1993; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês
10.1159/000474637
ISSN1873-7560
AutoresIan A. Aaronson, Ross Rames, William B. Greene, Lyle G. Walsh, Ulrich A. Hasal, Paul D. Garen,
Tópico(s)Gastroesophageal reflux and treatments
ResumoWe set out to determine experimentally whether particles of polytetrafluoroethylene migrate to the lungs and brain when relatively small volumes of Teflon paste are injected into the bladder in the manner used to correct reflux. Numerous particles of polytetrafluoroethylene were recovered from these organs within 2 weeks of injection. Those in the brain measured up to 15 pm in diameter, indicating that the pulmonary bed is an inefficient filter of particles gaining access to the venous circulation. Although clinically no adverse neurological effects have hitherto been reported, this study suggests that following the 'sting' procedure, some particles may lodge in the brain where they can block the cerebral microcirculation. We believe these findings represent a contraindication to the use of Teflon paste in children.
Referência(s)