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A Trisialoganglioside Containing a Sialyl α2-6 N-Acetylgalactosamine Residue Is a Cholinergic-Specific Antigen, Chol-1α1

1992; Oxford University Press; Volume: 111; Issue: 3 Linguagem: Inglês

10.1093/oxfordjournals.jbchem.a123751

1756-2651

Susumu Ando, Yoshio Hirabayashi, Kazuo Kon, Fuyuhiko Inagaki, Kiyohide Kojima, Shin‐ichi Tate, Victor P. Whittaker,

Galectins and Cancer Biology

Cholinergic-specific antigens termed the Chol-1 family have been suggested to be of a ganglioside nature by Richardson et al. (J. Neurochem. 38, 1606–1614, 1982). Two molecular species of polysialogangliosides among bovine brain gangliosides were found to react with anti-Chol-1α antiserum. One of them, Chol-1α-a, was isolated and characterized as a trisialoganglioside containing the gangliotetraose backbone in which 1 mol of sialic acid was attached to each of the reducing end galactose, iV-acetylgalactosamine and internal galactose residues, respectively. The chemical structure of Chol-1α-a was determined for the first time, being as follows: IV3NeuAc III6NeuAc II3NeuAc-GgOse4 Cer.