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A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation

2015; American Association for the Advancement of Science; Volume: 349; Issue: 6245 Linguagem: Inglês

10.1126/science.aab2276

1095-9203

Anand Minajigi, John E. Froberg, Chunyao Wei, Hongjae Sunwoo, Barry Kesner, David Colognori, Derek Lessing, Bernhard Payer, Myriam Boukhali, Wilhelm Haas, Jeannie T. Lee,

RNA and protein synthesis mechanisms

Protein partners for chromosome silencing Female mammals have two X chromosomes, one of which is almost completely shut down during development. The long noncoding Xist RNA plays a role in this process. To understand how a whole chromosome can be stably inactivated, Minajigi et al. identified many of the proteins that bind to the Xist RNA, which include cohesins. Paradoxically, the interaction between Xist and cohesin subunits resulted in repulsion of cohesin complexes from the inactive X chromosome, changing the three-dimensional shape of the whole chromosome. Science , this issue 10.1126/science.aab2276