Portal de Periódicos da CAPES

Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors

1997; American Psychiatric Association; Volume: 154; Issue: 1 Linguagem: Inglês

10.1176/ajp.154.1.50

1535-7228

Nora D. Volkow, G J Wang, Joanna S. Fowler, Jean Logan, Burt Angrist, R. Hitzemann, J.A. Lieberman, N. Pappas,

Advanced Neuroimaging Techniques and Applications

Back to table of contents Previous article Next article Full AccessEffects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptorsPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.154.1.50AboutSectionsView articleAbstractView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assess the pattern of metabolic responses associated with enhanced dopamine activity. METHOD: They used positron emission tomography with 2-deoxy-2[18F]fluoro-D-glucose to evaluate the effects of two sequential doses of methylphenidate on brain metabolism in 15 healthy subjects. Dopamine D2 receptor availability was measured with [11C]raclopride to evaluate its relation to methylphenidate-induced metabolic changes. RESULTS: Methylphenidate increased brain metabolism in six subjects, decreased it in two, and did not change it in seven; however, it consistently increased cerebellar metabolism. Methylphenidate significantly increased "relative" (region relative to the whole brain) metabolism in the cerebellum and decreased it in the basal ganglia. Regional metabolic changes in the cerebellum and the frontal and temporal cortices were significantly correlated with D2 availability. Frontal and temporal metabolism were increased in subjects with high D2 receptors and decreased in subjects with low D2 receptors. CONCLUSIONS: Methylphenidate induced variable changes in brain metabolism, but it consistently increased cerebellar metabolism. It also induced a significant reduction in relative metabolism in the basal ganglia. The significant association between metabolic changes in the frontal and temporal cortices and in the cerebellum and D2 receptors suggests that methylphenidate's metabolic effects in these brain regions are due in part to dopamine changes and that differences in D2 receptors may be one of the mechanisms accounting for the variability in response to methylphenidate. FiguresReferencesCited byDetailsCited ByAtypical spatiotemporal activation of cerebellar lobules during emotional face processing in adolescents with autism2 February 2021 | Human Brain Mapping, Vol. 103Indole Tryptophan Metabolism and Cytokine S100B in Children with Attention-Deficit/Hyperactivity Disorder: Daily Fluctuations, Responses to Methylphenidate, and Interrelationship with Depressive SymptomatologyJournal of Child and Adolescent Psychopharmacology, Vol. 30, No. 3Comorbid brain disorders associated with diabetes: therapeutic potentials of prebiotics, probiotics and herbal drugs19 July 2019 | Translational Medicine Communications, Vol. 4, No. 1Methylphenidate's effects on thalamic metabolism and functional connectivity in cannabis abusers and healthy controls1 December 2018 | Neuropsychopharmacology, Vol. 44, No. 8Biological Psychiatry, Vol. 86, No. 5Neuroimaging of compulsive disordersVentral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity18 June 2018 | Translational Psychiatry, Vol. 8, No. 1GLP-1 signaling and alcohol-mediated behaviors; preclinical and clinical evidenceNeuropharmacology, Vol. 136The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbiditiesNeuroscience & Biobehavioral Reviews, Vol. 87Movement Disorders Clinical Practice, Vol. 5, No. 3Brain Imaging and Behavior, Vol. 12, No. 2European Neuropsychopharmacology, Vol. 28, No. 4Attention-Deficit/Hyperactivity DisorderDiversities of behavioral traits and neuropsychological function in different substance addictionProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 78NeuroImage: Clinical, Vol. 13Psychological Medicine, Vol. 46, No. 13Neuropsychopharmacology, Vol. 41, No. 10Human Brain Mapping, Vol. 36, No. 1European Archives of Psychiatry and Clinical Neuroscience, Vol. 265, No. 4ToF-SIMS imaging of lipids and lipid related compounds in Drosophila brain13 June 2014 | Surface and Interface Analysis, Vol. 46, No. S1, Vol. 69, Vol. 211Biological Psychiatry, Vol. 76, No. 8NeuroImage, Vol. 89Neuropsychologia, Vol. 56The Journals of Gerontology: Series A, Vol. 69, No. 11Addiction Biology, Vol. 19, No. 3Addiction, Vol. 109, No. 9European Neuropsychopharmacology, Vol. 23, No. 10European Neuropsychopharmacology, Vol. 23, No. 11Neuroscience & Biobehavioral Reviews, Vol. 37, No. 9NeuroImage, Vol. 72Journal of korean Academy of Child and Adolescent Psychiatry, Vol. 24, No. 1Effects of methylphenidate on basic and higher-order oculomotor functions14 May 2012 | Journal of Psychopharmacology, Vol. 26, No. 11Cognitive and emotional behavioural changes associated with methylphenidate treatment: a review of preclinical studies25 March 2011 | The International Journal of Neuropsychopharmacology, Vol. 15, No. 01Human Psychopharmacology: Clinical and Experimental, Vol. 27, No. 6Journal of Psychiatric Research, Vol. 46, No. 1NeuroImage, Vol. 60, No. 2PLoS ONE, Vol. 7, No. 11Psychopharmacology, Vol. 216, No. 2Biological Psychiatry, Vol. 70, No. 3Neuropsychopharmacology, Vol. 36, No. 8Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetaminePsychiatric Genetics, Vol. 20, No. 3Psychopharmacology, Vol. 209, No. 4Proceedings of the National Academy of Sciences, Vol. 107, No. 4European Journal of Neuroscience, Vol. 32, No. 4Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats30 April 2009 | Psychopharmacology, Vol. 205, No. 2Journal of Labelled Compounds and RadiopharmaceuticalsPsychiatry Research: Neuroimaging, Vol. 174, No. 2Getting Children With Attention Deficit Hyperactivity Disorder to School on Time4 January 2008 | Journal of Family Issues, Vol. 29, No. 7Psychopharmacology, Vol. 199, No. 3Neuroscience Letters, Vol. 432, No. 1Annals of the New York Academy of Sciences, Vol. 1141, No. 1The Consequences of Attention-Deficit/Hyperactivity Disorder in AdultsJournal of Psychiatric Practice, Vol. 13, No. 5Human Brain Mapping, Vol. 28, No. 7Journal of Neural Transmission, Vol. 114, No. 12Brain Research, Vol. 1171Journal of Psychiatric Research, Vol. 41, No. 6Pharmacology Biochemistry and Behavior, Vol. 87, No. 4Developmental Medicine & Child Neurology, Vol. 43, No. 11Journal of Addictive Diseases, Vol. 26, No. sup1Clinical Drug Investigation, Vol. 27, No. 10Neurochemistry of ADHD28 February 2013European Archives of Psychiatry and Clinical Neuroscience, Vol. 256, No. S1Brain Research, Vol. 1114, No. 1Journal of Neuroscience Methods, Vol. 151, No. 1NeuroImage, Vol. 32, No. 4Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 30, No. 7Neuropsychobiology, Vol. 53, No. 4Brain Research Reviews, Vol. 48, No. 1Clinical Neurophysiology, Vol. 116, No. 2NeuroImage, Vol. 26, No. 4Psychiatry, Vol. 4, No. 12Neurobiologic Processes in Drug Reward and AddictionHarvard Review of Psychiatry, Vol. 12, No. 6Synapse, Vol. 51, No. 3Biological Psychiatry, Vol. 56, No. 8Drug and Alcohol Dependence, Vol. 76, No. 2Seminars in Nuclear Medicine, Vol. 34, No. 2Neurotoxicity Research, Vol. 5, No. 1-2Neuropsychopharmacology, Vol. 28, No. 5Journal of Child and Adolescent Psychopharmacology, Vol. 13, No. 1Effects of Methylphenidate on Functional Magnetic Resonance Relaxometry of the Cerebellar Vermis in Boys With ADHDCarl M. Anderson, Ph.D., Ann Polcari, R.N., Ph.D., Steven B. Lowen, Ph.D., Perry F. Renshaw, M.D., Ph.D., and Martin H. Teicher, M.D., Ph.D.1 August 2002 | American Journal of Psychiatry, Vol. 159, No. 8Clinical Implications of a Link between Fetal Alcohol Spectrum Disorder and Attention-Deficit Hyperactivity Disorder1 May 2002 | The Canadian Journal of Psychiatry, Vol. 47, No. 4Synapse, Vol. 43, No. 3Synapse, Vol. 46, No. 2NeuroToxicology, Vol. 23, No. 4-5Behavioural Brain Research, Vol. 130, No. 1-2Nature Reviews Neuroscience, Vol. 3, No. 8Journal of Psychiatric Practice, Vol. 8, No. 2Biological Psychiatry, Vol. 49, No. 8Current Opinion in Psychiatry, Vol. 14, No. 4Association Between Age-Related Decline in Brain Dopamine Activity and Impairment in Frontal and Cingulate MetabolismNora D. Volkow, M.D., Jean Logan, Ph.D., Joanna S. Fowler, Ph.D., Gene-Jack Wang, M.D., Ruben C. Gur, Ph.D., Christopher Wong, M.S., Christoph Felder, Ph.D., S. John Gatley, Ph.D., Yu-Shin Ding, Ph.D., Robert Hitzemann, Ph.D., and Naomi Pappas, M.S.1 January 2000 | American Journal of Psychiatry, Vol. 157, No. 1Nature Medicine, Vol. 6, No. 4Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans2 July 2016 | Journal of Psychopharmacology, Vol. 13, No. 4Association of Methylphenidate-Induced Craving With Changes in Right Striato-orbitofrontal Metabolism in Cocaine Abusers: Implications in AddictionNora D. Volkow, M.D., Gene-Jack Wang, M.D., Joanna S. Fowler, Ph.D., Robert Hitzemann, Ph.D., Burton Angrist, M.D., Samuel J. Gatley, Ph.D., Jean Logan, Ph.D., Yu-Shin Ding, Ph.D., and Naomi Pappas, M.S.1 January 1999 | American Journal of Psychiatry, Vol. 156, No. 1Mental Retardation and Developmental Disabilities Research Reviews, Vol. 5, No. 3Magnetic Resonance in Medicine, Vol. 42, No. 2Evaluation of Cerebellar Size in Attention-Deficit Hyperactivity Disorder2 July 2016 | Journal of Child Neurology, Vol. 13, No. 9Reviews : Pharmacotherapy of adolescent attention deficit hyperactivity disorder: challenges, choices and caveats2 July 2016 | Journal of Psychopharmacology, Vol. 12, No. 4Sex Differences in the Striatal Dopamine D2 Receptor Binding Characteristics in VivoTiina Pohjalainen, M.Sc., Juha O. Rinne, M.D., Kjell Någren, Ph.D., Erkka SyvÄlahti, M.D., and Jarmo Hietala, M.D.1 June 1998 | American Journal of Psychiatry, Vol. 155, No. 6Decline of Dopamine: Effects of Age and Acute Neuroleptic Challenge1 March 1998 | American Journal of Psychiatry, Vol. 155, No. 3Drug and Alcohol Dependence, Vol. 51, No. 1-2Psychiatry Research: Neuroimaging, Vol. 83, No. 1Proceedings of the National Academy of Sciences, Vol. 95, No. 24, Vol. 41 Volume 154Issue 1 January 1997Pages 50-55 Metrics History Published online 1 April 2006 Published in print 1 January 1997