Portal de Periódicos da CAPES

Alternatives to lithium for preventive treatment of bipolar disorder

1989; American Psychiatric Association; Volume: 146; Issue: 7 Linguagem: Inglês

10.1176/ajp.146.7.840

1535-7228

Robert F. Prien, A J Gelenberg,

Bipolar Disorder and Treatment

Back to table of contents Previous article Next article No AccessAlternatives to lithium for preventive treatment of bipolar disorderPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.146.7.840AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractThe authors review the research literature on drug treatment for the prevention of recurrences in bipolar disorder, emphasizing the available alternatives to lithium therapy. They discuss the need for alternative treatments and the current status of promising agents. Carbamazepine receives special attention because of its status as the most promising backup treatment for lithium. The authors conclude that despite the extensive literature on carbamazepine, there is strong need for carefully designed, prospective, double-blind studies to establish the efficacy of carbamazepine alone and in combination with lithium as a prophylactic treatment for bipolar disorder. Difficulties in developing and evaluating preventive maintenance are discussed. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byBipolar IllnessBipolar (Manic Depressive) Disorders20 February 2015Journal of Psychopharmacology, Vol. 20, No. 2_supplAustralian and New Zealand Clinical Practice Guidelines for the Treatment of Bipolar Disorder26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 38, No. 5Australian and New Zealand Journal of Psychiatry, Vol. 38, No. 5Expert Opinion on Pharmacotherapy, Vol. 5, No. 5Nuevos anticonvulsivantes en la profilaxis del trastorno bipolar12 May 2020 | European psychiatry (Ed. Española), Vol. 10, No. 8Medication prescribing patterns for patients with bipolar I disorder in hospital settings: adherence to published practice guidelines7 July 2008 | Bipolar Disorders, Vol. 3, No. 4Journal of Affective Disorders, Vol. 67, No. 1-3Lamotrigine for the Treatment of Bipolar Disorder28 June 2016 | Annals of Pharmacotherapy, Vol. 34, No. 2Journal of Affective Disorders, Vol. 59The costs of treatment of bipolar disorderPsychiatric Clinics of North America, Vol. 22, No. 3The American Journal of Geriatric Psychiatry, Vol. 7, No. 3Clozapine in bipolar disorder: treatment implications for other atypical antipsychoticsJournal of Affective Disorders, Vol. 48, No. 2-3Journal of Affective Disorders, Vol. 50, No. 2-3Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 22, No. 3Journal of Clinical Psychopharmacology, Vol. 18, No. 6Journal of Clinical Epidemiology, Vol. 50, No. 9CNS Spectrums, Vol. 2, No. 10British Journal of Psychiatry, Vol. 170, No. 3Psychiatric Bulletin, Vol. 20, No. 10Course and outcome in bipolar affective disorder: a longitudinal follow- up study1 April 2006 | American Journal of Psychiatry, Vol. 152, No. 3Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk1 April 2006 | American Journal of Psychiatry, Vol. 152, No. 3Child and Adolescent Psychiatric Clinics of North America, Vol. 4, No. 2The Therapeutic Challenge of Rapid Cycling Bipolar DisorderPsychiatric Annals, Vol. 24, No. 8Lithium Maintenance Therapy for Bipolar I Patients: Possible Refractoriness to Reinstitution after Discontinuation6 December 2016 | Psychological Reports, Vol. 74, No. 2Combining Lithium and Sodium Valproate for Bipolar Disorder26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 28, No. 1Depression, Vol. 2, No. 4Human Psychopharmacology: Clinical and Experimental, Vol. 9, No. 5Journal of Affective Disorders, Vol. 30, No. 4British Journal of Psychiatry, Vol. 164, No. 2Depression, Vol. 1, No. 1Medicinal Research Reviews, Vol. 13, No. 3Journal of Affective Disorders, Vol. 28, No. 4European Neuropsychopharmacology, Vol. 3, No. 2Psychosomatics, Vol. 34, No. 5Psychiatric Clinics of North America, Vol. 16, No. 3Irish Journal of Psychological Medicine, Vol. 10, No. 2Acta Neuropsychiatrica, Vol. 5, No. 3British Journal of Psychiatry, Vol. 163, No. S21Lithium Treatment: Relationship Between Relapses and Personality DisordersVerapamil and Valproic Acid Treatment of Prolonged ManiaJournal of the American Academy of Child & Adolescent Psychiatry, Vol. 31, No. 2Seizure with low doses of clozapine1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 1Flunarizine as maintenance treatment of a patient with bipolar disorder1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 1Methadone treatment of Tourette's disorder1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 1Treatment of bipolar disorder ∗1 October 1991 | Medical Journal of Australia, Vol. 155, No. 7Effects of administering antidepressants to patients receiving ECT1 April 2006 | American Journal of Psychiatry, Vol. 148, No. 6Use of maintenance ECT for elderly depressed patients1 April 2006 | American Journal of Psychiatry, Vol. 148, No. 6The clonidine test in posttraumatic stress disorder1 April 2006 | American Journal of Psychiatry, Vol. 148, No. 6Mania in an elderly man treated with bupropion1 April 2006 | American Journal of Psychiatry, Vol. 148, No. 4Malignant hyperthermia during ECT1 April 2006 | American Journal of Psychiatry, Vol. 148, No. 4General Hospital Psychiatry, Vol. 13, No. 2Psychiatric Clinics of North America, Vol. 14, No. 4, Vol. 36Acta Psychiatrica Scandinavica, Vol. 84, No. 1Rapid opioid detoxification with electrosleep and naloxone1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 7Adequacy of Pharmacological TreatmentJACQUES BRADWEJN, and GREG B. METERISSIAN1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 7Adequacy of pharmacological treatment1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 7ECT as an alternative to lithium for preventive treatment of bipolar disorder1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 7Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 4Relapse following discontinuation of lithium maintenance therapy in adolescents with bipolar I illness: a naturalistic study1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 4Role of psychotherapy in bipolar disorder1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 4P.T. Barnum and the Borderline Personality Disorder MuddleVICTOR S. ALPHER1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 4Dr. Swartz RepliesMARVIN S. SWARTZ1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 4P.T. Barnum and the borderline personality disorder muddle23 January 2015 | American Journal of Psychiatry, Vol. 147, No. 4ECT as prophylactic treatment for bipolar disorder1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 3Sleep Disturbance in Posttraumatic Stress DisorderRICHARD J. ROSS, WILLIAM A. BALL, KENNETH A. SULLIVAN, and STANLEY N. CAROFF1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 3Sleep Disturbance in Posttraumatic Stress DisorderMORTIMER OSTOW1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 3Sleep disturbance in posttraumatic stress disorder23 January 2015 | American Journal of Psychiatry, Vol. 147, No. 3 Volume 146Issue 7 July 1989Pages 840-848 Metrics PDF download History Published online 1 April 2006 Published in print 1 July 1989