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Hepatitis B virus surface antigen and anti‐hepatitis C virus rapid tests underestimate hepatitis prevalence among HIV ‐infected patients

2014; Wiley; Volume: 15; Issue: 9 Linguagem: Inglês

10.1111/hiv.12158

1468-1293

Bo Langhoff Hønge, Sanne Jespersen, C. Medina, DS Té, ZJ da Silva, Lars Østergaard, Alex Lund Laursen, Christian Wejse, Henrik Krarup, Christian Erikstrup,

Liver Disease Diagnosis and Treatment

Objectives In the case of coinfection with HIV and hepatitis B virus ( HBV ) and/or hepatitis C virus ( HCV ), hepatic disease progression is often accelerated, with higher rates of liver cirrhosis and liver‐related mortality. We aimed to evaluate the performance of the rapid tests used routinely to detect HBV surface antigen ( HBsAg ) and anti‐ HCV among HIV ‐infected patients in G uinea‐ B issau. Methods Blood samples from HIV ‐infected patients in G uinea‐ B issau were stored after testing for HBsAg and anti‐ HCV with rapid tests. Samples were subsequently re‐tested for HBsAg and anti‐ HCV in D enmark. Results Two rapid tests were used in G uinea‐ B issau: HBsAg Strip Ref 2034 ( VEDA . LAB , Alençon, F rance; sensitivity 62.3%; specificity 99.2%) and HEPA‐SCAN ( B hat B io‐ T ech, B angalore, I ndia; sensitivity 57.1%; specificity 99.7%). In the two tests the ability to obtain the correct outcome depended on the antigen and antibody concentrations, respectively. Sex, age, CD4 cell count and antiretroviral therapy status did not differ between false negative and true positive samples in either of the tests. The study is limited by a low number of anti‐ HCV positive samples. Conclusions New diagnostic rapid tests should always be evaluated in the setting in which they will be used before implementation.