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Immunization with newly transformed Schistosoma mansoni schistosomula tegument elicits tegument damage, reduction in egg and parasite burden

2010; Wiley; Volume: 32; Issue: 11-12 Linguagem: Inglês

10.1111/j.1365-3024.2010.01244.x

1365-3024

Tatiane Teixeira de Melo, Juliano Michel de Araújo, Fernanda do Valle Durães, Marcelo Vidigal Caliari, Sérgio C. Oliveira, Paulo Marcos Zech Coelho, Cristina Toscano Fonseca,

Helminth infection and control

Summary The surface of the schistosomula is an important target for host immune system attack because the tegument represents the interface between host and parasite and thus is a potential candidate for the development of new intervention strategies. In this study, we evaluated the ability of schistosomula tegument (Smteg) to induce protection in mice. Immunization of mice with Smteg together with Freund adjuvant induced a Th1 type of immune response associated with a significant reduction in worm burden (43–48%), eggs trapped in the liver (65%), eggs eliminated in the faeces (59–60%) and granuloma number (41%). Lastly, during an in vitro study, worms from mice immunized with Smteg showed damage in the adult worm tegument and impaired egg laying.