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Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates

1995; American Psychiatric Association; Volume: 152; Issue: 6 Linguagem: Inglês

10.1176/ajp.152.6.907

1535-7228

Patrick T. Mehlman, J. Dee Higley, I Faucher, Alecia A. Lilly, D. Taub, James H. Vickers, S.J. Suomi, M. Linnoila,

Memory and Neural Mechanisms

Back to table of contents Previous article Next article No AccessCorrelation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primatesPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.152.6.907AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: The purpose of this study was to examine the relationship between behavior and serotonin in nonhuman primates. METHOD: During a routine capture and medical examination, 26 adolescent male rhesus macaques (Macaca mulatta) were selected as subjects from a free-ranging population of 4,500 rhesus monkeys inhabiting a 475-acre sea island. Blood samples (N = 23) and CSF samples (N = 22) were obtained, and each subject was fitted with a radio transmitter collar for rapid location. The subjects were released into their social groups, and quantitative behavioral observations were made over a 3-month period. RESULTS: CSF 5- hydroxyindoleacetic acid (5-HIAA) concentration was positively correlated with three measures of sociality: 1) total time spent grooming others, 2) total time spent in close proximity to other group members, and 3) mean number of neighbors within a 5-m radius. In addition, CSF 5-HIAA concentration was positively correlated with age at emigration from the natal group (in months). CONCLUSIONS: In adolescent male rhesus macaques living in naturalistic settings, CSF 5- HIAA concentration is positively correlated with affiliative sociality. Rhesus males with low CSF 5-HIAA concentrations exhibit less social competence and emigrate from their social groups at a younger age than do males with higher concentrations of CSF 5-HIAA. Access content To read the fulltext, please use one of the options below to sign in or purchase access. 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