EXPRESSION OF H-2 SPECIFICITIES AND OF MuLV ENVELOPE ANTIGENS ON MURINE TUMORS
1977; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-12-458050-3.50043-6
AutoresVolker Schirrmacher, Federico Garrido,
Tópico(s)Virus-based gene therapy research
ResumoThis chapter explores the possible changes in H-2 antigen expression on virus-infected cells and on tumor cells. Anomalous cytotoxic reactions of anti H-2 sera with murine tumor cells have been detected before, and some recent studies suggest that these reactions are caused by antibodies against envelope antigens of murine leukemia viruses (MuLV). Experiments have been performed on anomalous reactions of anti H-2 sera with murine tumor cells that occur with a frequency of about 20%, that show a complex pattern of distribution, and that do not or not always seem to be directed against MuLV antigens. Absorption experiments reveal that extra H-2 reactions could also be induced in murine tumors by viruses. All results in this chapter suggest that anti H-2 sera can detect on tumor cells apart from the normal H-2 specificities and from antigens of endogenous MuLV.
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