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Very Early Recurrence of Anti-Phospholipase A2 Receptor-Positive Membranous Nephropathy After Transplantation

2012; Elsevier BV; Volume: 12; Issue: 6 Linguagem: Inglês

10.1111/j.1600-6143.2011.03957.x

1600-6143

Christopher D. Blosser, Rivka Ayalon, Rajesh Nair, Christie P. Thomas, Laurence H. Beck,

Platelet Disorders and Treatments

Membranous nephropathy is a common cause of adult nephrotic syndrome, with recent evidence suggesting that 70% of idiopathic disease is associated with anti-Phospholipase A2 receptor autoantibodies. We describe a 63-year-old man with membranous nephropathy who underwent a kidney transplant and developed recurrent membranous nephropathy with fine granular co-localization of Phospholipase A2 receptor and IgG evident on transplant biopsy on day 6 and elevated circulating levels of serum anti-Phospholipase A2 receptor autoantibody that declined over time in conjunction with improvement in the serum creatinine and urinary protein. This is a very early case of Phospholipase A2 receptor-associated recurrent membranous nephropathy with circulating anti-Phospholipase A2 receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.