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Continuous Veno-Venous Hemofiltration in the Treatment of Acute Severe Hyponatremia: A Report of 11 Cases

2007; SAGE Publishing; Volume: 30; Issue: 2 Linguagem: Inglês

10.1177/039139880703000213

1724-6040

Di Ji, Dehua Gong, Biao Xu, Jing Tao, Bingzhong Ren, Yang Zhang, Yuchen Liu, Weixin Hu, Meng-Han Wang, L.S. Li,

Renal function and acid-base balance

Objectives To evaluate the treatment effect of continuous veno-venous hemofiltration (CVVH) in patients with acute severe hyponatremia. Methods Eleven patients with severe acute hyponatremia, including 6 males and 5 females, aged 25–61 years (mean age 48.36), were treated with CVVH. Hyponatremia occurred 38–48 hours prior to the initiation of CVVH. Results All patients tolerated CVVH well, with an average treatment duration of 57.19 (45.6–86) hours. During CVVH, the serum sodium concentration increased significantly from 100.9±3.99 mmol/L at initiation of CVVH to 140.3±1.6 mmol/L after 48 hours of treatment (P<0.01). The serum osmolarity increased concurrently, from 216.7±7.4 mOsm/kgH 2 O to 295.0±4.2 mOsm/kgH 2 O (P<0.01). The Glasgow scores and APACHE II scores in these patients improved significantly during treatment. Conclusions CVVH is a safe and effective option for the treatment of patients with severe acute hyponatremia due to its slow and continuous nature.