Amino acid derivatives. Part I. Synthesis, antiviral and antitumor evaluation of new alpha-amino acid esters bearing coumarin side chain.
2006; De Gruyter Open; Volume: 56; Issue: 2 Linguagem: Inglês
ISSN
1846-9558
AutoresNajim A. Al‐Masoudi, Iman A. Al‐Masoudi, Ibrahim A. I. Ali, Yaseen A. Al‐Soud, Bahjat A. Saeed, Paolo La Colla,
Tópico(s)Synthesis and Biological Evaluation
ResumoA series of amino acid esters bearing coumarin (3-15) were synthesized and evaluated, in vitro, against HIV-1, and bovine viral diarrhea virus (BVDV). The in vitro cytotoxicity of 3-10 and 12 was assayed against a panel of tumor cell lines consisting of CD4 human T-cells. Compound 14 showed inhibition of HIV-1 with EC50 > 1.6 microg mL(-1), meanwhile compound 9 exhibited activity against leukaemia (MT4) with CC50 = 24 micromol L(-1).
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