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Study of Flow-Induced Hemolysis Using Novel Couette-Type Blood-Shearing Devices

2011; Wiley; Volume: 35; Issue: 12 Linguagem: Inglês

10.1111/j.1525-1594.2011.01243.x

1525-1594

Tao Zhang, Mustafa Taşkın, Hong‐Bin Fang, Adam Pampori, Robert Jarvik, Bartley P. Griffith, Zhongjun J. Wu,

Mechanical Circulatory Support Devices

Artificial OrgansVolume 35, Issue 12 p. 1180-1186 Study of Flow-Induced Hemolysis Using Novel Couette-Type Blood-Shearing Devices Tao Zhang, Tao Zhang Artificial Organs Laboratory, Department of Surgery, University of Maryland BaltimoreSearch for more papers by this authorM. Ertan Taskin, M. Ertan Taskin Artificial Organs Laboratory, Department of Surgery, University of Maryland BaltimoreSearch for more papers by this authorHong-Bin Fang, Hong-Bin Fang Division of Biostatistics, Department of Epidemiology and Preventive Medicine, University of Maryland Baltimore, BaltimoreSearch for more papers by this authorAdam Pampori, Adam Pampori Department of Bioengineering, University of Maryland, College Park, MDSearch for more papers by this authorRobert Jarvik, Robert Jarvik Jarvik Heart, Inc., New York, NY, USASearch for more papers by this authorBartley P. Griffith, Bartley P. Griffith Artificial Organs Laboratory, Department of Surgery, University of Maryland BaltimoreSearch for more papers by this authorZhongjun J. Wu, Corresponding Author Zhongjun J. Wu Artificial Organs Laboratory, Department of Surgery, University of Maryland BaltimoreDr. Zhongjun J. Wu, Department of Surgery, University of Maryland Baltimore, MSTF-436, 10 South Pine Street, Baltimore, MD 21201, USA. E-mail: zwu@smail.umaryland.eduSearch for more papers by this author Tao Zhang, Tao Zhang Artificial Organs Laboratory, Department of Surgery, University of Maryland BaltimoreSearch for more papers by this authorM. Ertan Taskin, M. Ertan Taskin Artificial Organs Laboratory, Department of Surgery, University of Maryland BaltimoreSearch for more papers by this authorHong-Bin Fang, Hong-Bin Fang Division of Biostatistics, Department of Epidemiology and Preventive Medicine, University of Maryland Baltimore, BaltimoreSearch for more papers by this authorAdam Pampori, Adam Pampori Department of Bioengineering, University of Maryland, College Park, MDSearch for more papers by this authorRobert Jarvik, Robert Jarvik Jarvik Heart, Inc., New York, NY, USASearch for more papers by this authorBartley P. Griffith, Bartley P. Griffith Artificial Organs Laboratory, Department of Surgery, University of Maryland BaltimoreSearch for more papers by this authorZhongjun J. Wu, Corresponding Author Zhongjun J. Wu Artificial Organs Laboratory, Department of Surgery, University of Maryland BaltimoreDr. Zhongjun J. Wu, Department of Surgery, University of Maryland Baltimore, MSTF-436, 10 South Pine Street, Baltimore, MD 21201, USA. E-mail: zwu@smail.umaryland.eduSearch for more papers by this author First published: 02 August 2011 https://doi.org/10.1111/j.1525-1594.2011.01243.xCitations: 109Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract To assist the development and application of blood-contacting medical devices, two novel flow-through Couette-type blood-shearing devices have been developed to study the quantitative relationship between blood damage indexes and flow-dependent parameters. One device is an axial flow-through Couette-type device supported by a pair of pin bearings adapted from the adult Jarvik 2000 blood pump. The other is a centrifugal flow-through Couette-type device supported with magnetic bearings adapted from the CentriMag blood pump. In both devices, a rotor spindle was used to replace the original impeller blades so that a small gap was created between the housing and the rotating spindle surface. Computational fluid dynamics simulations have shown that a uniform, high shear stress region can be generated inside the small gap while the shear stresses elsewhere are relatively low. The possibility of secondary blood damage caused by mechanical seals was eliminated due to the use of a magnetic rotor system. Blood flow through the gap was driven by an externally pressurized reservoir. By adjusting the rotational speed and blood flow rate, shear-induced hemolysis was quantified at a matrix of exposure time (0.039 to 1.48 s) and shear stress (50 to 320 Pa). All of the experiments were conducted at room temperature using heparinized ovine blood with a hematocrit value of 30%. The measured hemolysis levels were much lower than those published in the literature, and the overestimation of those earlier studies may be attributable to device-related secondary blood-damaging effects. A new set of coefficients for the power law model was derived from the regression of the experimental data. Citing Literature Volume35, Issue12December 2011Pages 1180-1186 RelatedInformation