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Fructose 2,6-Bisphosphate versus Cyclic AMP in the Liver and in Lower Eukaryotic Cells

1985; Academic Press; Linguagem: Inglês

10.1016/b978-0-12-152827-0.50041-4

0070-2137

H G Hers, Jean François, Emile Van Schaftingen,

Pancreatic function and diabetes

This chapter focuses on the control of Fru-2,6-P2 concentration in liver and in Saccharomyces cerevisiae. It has been recognized that heat-activated spores form transiently cyclic AMP and that they form more of it in the presence than in the absence of glucose. Most of the knowledge on Fru-2,6-P2 originates from studies performed on the liver, and it appears now that the properties of the liver system do not necessarily apply to other types of cells. Dormancy is an arrest in development of fungal or bacterial spores or of seed embryos under conditions otherwise suited for growth. The dramatic increase in Fru-2,6-P2 concentration in various preparations of lower eukaryotes during the resumption of metabolic activity indicates that Fru-2,6-P2 might have other roles than the control of glycolysis and opens new perspectives of research in the field of developmental biochemistry. PFK 1 is not sensitive to Fru-2,6-P2 stimulation. The only enzyme sensitive to Fru-2,6-P2 in these cells is PPi:fructose-6-phosphate 1-phosphotransferase, the role of which is still quite obscure.