Chronic Calcifying Pancreatitis—Chronic Alcoholic Pancreatitis
1974; Elsevier BV; Volume: 66; Issue: 4 Linguagem: Inglês
10.1016/s0016-5085(74)80050-8
ISSN1528-0012
Autores Tópico(s)Alcohol Consumption and Health Effects
ResumoThe theory that chronic alcoholism might be a cause for chronic pancreatitis has been stressed by many authors, 1-3 However, details about the specific features and symptoms of chronic alcoholic pancreatitis have not been reported in very many studies, The aim of this report is to summarize the pathological and experimental data available, and to express some thoughts on the possible mechanisms involved in the development of the disease, Most of the work published during the last 20 years4, 5 expresses the view that the pathogenesis of chronic alcoholic pancreatitis is based on four hypotheses: (1) alcohol consumption results in considerable hypersecretion of pancreatic juice; (2) alcohol produces an obstruction to the flow of pancreatic juice; (3) the conflict between hypersecretion and obstruction to flow produces acute pancreatitis; (4) repeated acute attacks result in development of chronic pancreatitis,6Three of these hypotheses merit critical examination, 1.It is true that the ingestion of alcohol results in pancreatic secretion secondary to the passage of gastric acid secretion into the duodenum, This HCI secretion is itself initiated by at least two mechanisms: antral release of gastrin 7-9 and a mechanism unrelated to gastrin and probably of vagal origin,7, 10, 11 The secretion of gastrin may itself have a direct effect on pancreatic secretion, 12 Moreover, in the human sub-
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