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820 Urinary Peptide Analysis Differentiates Pancreatic Cancer From Chronic Pancreatitis

2013; Elsevier BV; Volume: 144; Issue: 5 Linguagem: Inglês

10.1016/s0016-5085(13)60515-6

1528-0012

Bastian Schoenemeier, Jochen Metzger, Jonas Rosendahl, Ruben R. Plentz, Johannes Wiegand, Harald Mischak, Michael P. Manns, Tim O. Lankisch,

Vitamin D Research Studies

was 619 pg/ml compared to 384 pg/ml in the CP unlikely group (p= 0.001).We observed a linear association between the number of EUS criteria and PGE2 levels: for each additional EUS criteria, mean PGE2 levels increased by 61pg/ml.This association was significant in both univariate ( β = 0.34, p= 0.03) and multivariate analysis (β = 0.35, p= 0.03) after adjusting for age, gender, and nonsteroidal anti-inflammatory drugs use.In contrast, bicarbonate levels decreased by 4.5 mEq/L with each additional EUS criteria (p= 0.04).The addition of PGE2 to bicarbonate improved the ROC for detection of MCCP from 62 to 72%.Conclusion: Pancreatic juice PGE2 levels are elevated in MCCP and correlate with the number of EUS features present.The association with EUS features is linear, suggesting a possible role of PGE2 levels for diagnosis of MCCP and the potential use of COX-2 inhibitors to halt disease progression at early stages.