Fluid produced by the gastric mucosa during damage by acetic and salicylic acids
1966; Elsevier BV; Volume: 50; Issue: 4 Linguagem: Inglês
10.1016/s0016-5085(66)80027-6
ISSN1528-0012
Autores Tópico(s)Renal function and acid-base balance
ResumoThe otherwise unstimulated mucosa of the oxyntic gland area of the stomach, when damaged by salicylates or fatty acids, produces a large volume of fluid.For example, the volume contained in a separated pouch of the dog's stomach irrigated with 20 mM salicylic acid in 100 mM Hel may increase from 35 to 55 ml within 30 min.!The four possible reasons for increased volume output are: (a) Damage, acting through some local humoral or nervous mechanism, may stimulate secretion of juice containing H +, K +, pepsin, and mucus.(b) Filtration may be increased as the result of elevated capillary pressure.Fluid entering the lumen would be derived from an ultrafiltrate of plasma; its protein content would depend upon the natural permeability of the mucosal capillaries and of the mucosa to protein.(c) If capillary permeability is increased by damage, an
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