Cell death decision by p53 via control of the mitochondrial membrane
2015; Elsevier BV; Volume: 367; Issue: 2 Linguagem: Inglês
10.1016/j.canlet.2015.07.019
ISSN1872-7980
AutoresNurmaa K. Dashzeveg, Kiyotsugu Yoshida,
Tópico(s)Cancer-related Molecular Pathways
ResumoThe tumor suppressor p53 is mutated in more than half of human cancers. Recent evidence has revealed that p53 not only regulates apoptosis but also regulates necrotic/necroptotic cell death via the mitochondria. The regulation of apoptosis by p53 is tightly connected to the mitochondrial outer membrane permeabilization and the induction of and interaction with Bcl-2 family members. Interestingly, p53-mediated regulation of necrosis/necroptosis is correlated with mitochondrial permeabilization pore opening via interactions with CypD and Drp1. This review discusses the p53-regulating molecules that induce apoptosis or necrosis/necroptosis via the mitochondria.
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