Portal de Periódicos da CAPES

Curcumin and Liver Disease: from Chemistry to Medicine

2013; Wiley; Volume: 13; Issue: 1 Linguagem: Inglês

10.1111/1541-4337.12047

1541-4337

Seyed Fazel Nabavi, Maria Daglia, Akbar Hajizadeh Moghaddam, Solomon Habtemariam, Seyed Mohammad Nabavi,

Drug-Induced Hepatotoxicity and Protection

Abstract Curcumin, the natural yellow‐colored active principle, also called turmeric yellow, extracted from the perennial herb Curcuma longa L., has potent biological and pharmacological properties such as antioxidant, anti‐inflammatory, antifungal, antibacterial, anti‐ischemic, antitumor, and anticancer actions. The molecular mechanism of the hepatoprotective action of curcumin is due to its antioxidant properties and inhibitory activity against nuclear factor (NF)‐κB that regulates different proinflammatory and profibrotic cytokines. Overall, scientific reports demonstrate that curcumin has high therapeutic ability for treating hepatic disorders. Here is a systematic discussion of the hepatoprotective activity of curcumin and its possible mechanisms of actions.