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The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real?

2015; Elsevier BV; Volume: 1; Issue: 1 Linguagem: Inglês

10.1016/j.trecan.2015.07.005

2405-8033

Ryan M. Thomas, Christian Jobin,

Cancer Genomics and Diagnostics

Investigations focused on the interplay between the human microbiome and cancer development, herein termed the 'oncobiome', have been growing at a rapid rate. However, these studies to date have primarily demonstrated associative relationships rather than causative ones. We pose the question of whether this emerging field of research is a 'mirage' without a clear picture, or truly represents a paradigm shift for cancer research. We propose the necessary steps needed to answer crucial questions and push the field forward to bring the mirage into a tangible reality.