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NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway

2015; Impact Journals LLC; Volume: 6; Issue: 28 Linguagem: Inglês

10.18632/oncotarget.4573

1949-2553

Jin-Ju Lei, Roujun Peng, Bo-Hua Kuang, Zhong-Yu Yuan, Tao Qin, Wensheng Liu, Yun-Miao Guo, Hui-Qiong Han, Yi-Fan Lian, Cheng-Cheng Deng, Hao-Jiong Zhang, Li-Zhen Chen, Qi-Sheng Feng, Miao Xu, Lin Feng, Jin‐Xin Bei, Yi-Xin Zeng,

Glycosylation and Glycoproteins Research

// Jin-Ju Lei 1, & , Rou-Jun Peng 2, &, * , Bo-Hua Kuang 1, & , Zhong-Yu Yuan 2 , Tao Qin 2 , Wen-Sheng Liu 1 , Yun-Miao Guo 1 , Hui-Qiong Han 1 , Yi-Fan Lian 1 , Cheng-Cheng Deng 1 , Hao-Jiong Zhang 1 , Li-Zhen Chen 1 , Qi-Sheng Feng 1 , Miao Xu 1 , Lin Feng 1 , Jin-Xin Bei 1, * , Yi-Xin Zeng 1, 3, * 1 Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China 2 Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China 3 Peking Union Medical College, Beijing, China & These authors contributed equally to this work * These authors jointly directed this study Correspondence to: Yi-Xin Zeng, e-mail: zengyx@sysucc.org.cn Jin-Xin Bei, e-mail: beijx@sysucc.org.cn Rou-Jun Peng, e-mail: pengrj@sysucc.org.cn Keywords: NOP14, breast cancer, NRIP1, Wnt/β-catenin pathway Received: May 15, 2015 Accepted: July 01, 2015 Published: July 13, 2015 ABSTRACT NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERα expression and inhibited the Wnt/β-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival ( P = 0.0006) and disease-free survival ( P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.