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BIBTEX RIS

Acute and Sub-Chronic Toxicity of Aqueous Extracts of Chenopodium ambrosioides Leaves in Rats

2014; Mary Ann Liebert, Inc.; Volume: 17; Issue: 9 Linguagem: Inglês

10.1089/jmf.2013.0134

ISSN

1557-7600

Autores

Marcel Gianni C. da Silva, Raimundo Neilson Lima Amorim, Carlos C. da Camara, J.D. Fontenele-Neto, Benito Soto‐Blanco,

Tópico(s)

Seed and Plant Biochemistry

Resumo

The present study aimed to evaluate the toxicity of aqueous extract of Chenopodium ambrosioides leaves. To measure acute toxicity, rats were administered 0, 0.3, 1.0, or 3.0 g/kg of aqueous extract from C. ambrosioides leaves by gavage. To analyze sub-chronic toxicity, rats were treated by oral gavage for 15 consecutive days with 0, 0.3, or 1.0 g/kg of extract of C. ambrosioides leaves. No animals from either trial exhibited any signs of toxicity. In the acute study, the highest dose of the extract led to an increase in the serum activities of alanine transaminase (ALT) and aspartate transaminase (AST) and a decrease in the serum levels of urea. In the sub-chronic test, rats treated with 1.0 g/kg for 15 days exhibited increased serum ALT activity and creatinine levels and mild cytoplasmic vacuolation of hepatocytes. The results indicate that aqueous extract from C. ambrosioides leaves produce slight hepatotoxic lesions in rats.

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