Artigo Revisado por pares

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.

1969; American Physiological Society; Volume: 32; Issue: 6 Linguagem: Inglês

10.1152/jn.1969.32.6.1025

ISSN

1522-1598

Autores

P Bessou, Edward R. Perl,

Tópico(s)

Neuroscience and Neural Engineering

Resumo

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli.P Bessou, and E R PerlP Bessou, and E R PerlPublished Online:01 Nov 1969https://doi.org/10.1152/jn.1969.32.6.1025MoreSectionsPDF (3 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsJNP CollectionsClassic ArticlesHistorical Articles Cited ByThe Role of Voltage-Gated Sodium Channels in Pain SignalingDavid L. Bennett, Alex J. Clark, Jianying Huang, Stephen G. Waxman, and Sulayman D. Dib-Hajj23 January 2019 | Physiological Reviews, Vol. 99, No. 2Insights into the evolution of polymodal chemoreceptorsActa Histochemica, Vol. 120, No. 7Timing Mechanisms Underlying Gate Control by Feedforward InhibitionNeuron, Vol. 99, No. 5Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity30 July 2018 | Journal of Clinical Investigation, Vol. 128, No. 9Pain and pain syndromesBritish Journal of Hospital Medicine, Vol. 79, No. 8Heat-resistant action potentials require TTX-resistant sodium channels Na V 1.8 and Na V 1.93 July 2018 | The Journal of General PhysiologyRole of TRPV1 in acupuncture modulation of reflex excitatory cardiovascular responsesZhi-Ling Guo,* Liang-Wu Fu,* Hou-Fen Su, Stephanie C. Tjen-A-Looi, and John C. Longhurst1 May 2018 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 314, No. 5Sensory Afferents Use Different Coding Strategies for Heat and ColdCell Reports, Vol. 23, No. 7Response to Phillips et al. (doi: 10.1089/neu.2017.5082): An Autonomic Neuroprosthesis: Non-Invasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord InjuryJournal of Neurotrauma, Vol. 35, No. 6Contribution of Plasma Membrane Calcium ATPases to neuronal maladaptive responses: Focus on spinal nociceptive mechanisms and neurodegenerationNeuroscience Letters, Vol. 663NaV1.7 and painPAINSparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors12 October 2017 | eLife, Vol. 6Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair PullNeuron, Vol. 95, No. 4Testing Assumptions in Human Pain Models: Psychophysical Differences Between First and Second PainThe Journal of Pain, Vol. 18, No. 3Hairy SensationStefan G. Lechner, and Gary R. Lewin1 May 2013 | Physiology, Vol. 28, No. 3The Molecular and Cellular Basis of Cold Sensation28 November 2012 | ACS Chemical Neuroscience, Vol. 4, No. 2Relationship between electrophysiological signature and defined sensory modality of trigeminal ganglion neurons in vivoM. Danilo Boada1 February 2013 | Journal of Neurophysiology, Vol. 109, No. 3Theories of pain: from specificity to gate controlMassieh Moayedi, and Karen D. Davis1 January 2013 | Journal of Neurophysiology, Vol. 109, No. 1CCL2 has similar excitatory effects to TNF-α in a subgroup of inflamed C-fiber axonsNatalie Richards, Thomas Batty, and Andrew Dilley1 December 2011 | Journal of Neurophysiology, Vol. 106, No. 6Differing Neurophysiologic Mechanosensory Input From Glabrous and Hairy Skin in Juvenile RatsM. Danilo Boada, Timothy T. Houle, James C. Eisenach, and Douglas G. Ririe1 December 2010 | Journal of Neurophysiology, Vol. 104, No. 6Thermoreception and nociception of the skin: a classic paper of Bessou and Perl and analyses of thermal sensitivity during a student laboratory exerciseJohann P. Kuhtz-Buschbeck, Wiebke Andresen, Stephan Göbel, René Gilster, and Carsten Stick1 June 2010 | Advances in Physiology Education, Vol. 34, No. 2Early Postnatal Loss of Heat Sensitivity Among Cutaneous Myelinated Nociceptors in Swiss–Webster MiceYi Ye, and C. Jeffery Woodbury1 March 2010 | Journal of Neurophysiology, Vol. 103, No. 3Cannabinoid Modulation of Cutaneous Aδ Nociceptors During InflammationCarl Potenzieri, Thaddeus S. Brink, Cholawat Pacharinsak, and Donald A. Simone1 November 2008 | Journal of Neurophysiology, Vol. 100, No. 5Synaptic Wiring in the Deep Dorsal Horn. Focus on "Local Circuit Connections Between Hamster Laminae III and IV Dorsal Horn Neurons"Yan Lu1 March 2008 | Journal of Neurophysiology, Vol. 99, No. 3Characterization of Mouse Lumbar Splanchnic and Pelvic Nerve Urinary Bladder Mechanosensory AfferentsLinjing Xu, and G. F. Gebhart1 January 2008 | Journal of Neurophysiology, Vol. 99, No. 1Physiological Properties of Mouse Skin Sensory Neurons Recorded Intracellularly In Vivo: Temperature Effects on Somal Membrane PropertiesM. Danilo Boada, and C. Jeffery Woodbury1 August 2007 | Journal of Neurophysiology, Vol. 98, No. 2Heat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 ProteinK. K. Rau, N. Jiang, R. D. Johnson, and B. Y. Cooper1 April 2007 | Journal of Neurophysiology, Vol. 97, No. 4Placing pain on the sensory map: Classic papers by Ed Perl and colleaguesPeggy Mason1 March 2007 | Journal of Neurophysiology, Vol. 97, No. 3Neurons in Superficial Trigeminal Subnucleus Caudalis Responsive to Oral Cooling, Menthol, and Other Irritant StimuliKaren L. Zanotto, Austin W. Merrill, Mirela Iodi Carstens, and E. Carstens1 February 2007 | Journal of Neurophysiology, Vol. 97, No. 2Transient receptor potential ion channels as participants in thermosensation and thermoregulationMichael J. Caterina1 January 2007 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 292, No. 1Ideas about pain, a historical view1 January 2007 | Nature Reviews Neuroscience, Vol. 8, No. 1Proton Sensitivity Ca2+ Permeability and Molecular Basis of Acid-Sensing Ion Channels Expressed in Glabrous and Hairy Skin AfferentsN. Jiang, K. K. Rau, R. D. Johnson, and B. Y. Cooper1 April 2006 | Journal of Neurophysiology, Vol. 95, No. 4Chemical and Cold Sensitivity of Two Distinct Populations of TRPM8-Expressing Somatosensory NeuronsHong Xing, Jennifer Ling, Meng Chen, and Jianguo G. Gu1 February 2006 | Journal of Neurophysiology, Vol. 95, No. 2Nicotinic AChR in Subclassified Capsaicin-Sensitive and -Insensitive Nociceptors of the Rat DRGK. K. Rau, R. D. Johnson, and B. Y. Cooper1 March 2005 | Journal of Neurophysiology, Vol. 93, No. 3Modification of Magnitude Estimations in Thermotactile Perception during Self-Generated and Externally Generated Movements25 June 2016 | Perception, Vol. 34, No. 2Mechanosensation and pain1 January 2004 | Journal of Neurobiology, Vol. 61, No. 1Temperature perception and nociception1 January 2004 | Journal of Neurobiology, Vol. 61, No. 1Aβ-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammalsBrain Research Reviews, Vol. 46, No. 2Effects of ropivacaine infiltration on cortisol and prolactin responses to postoperative pain after inguinal hernioraphy in childrenJournal of Pediatric Surgery, Vol. 39, No. 9Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activatorBrain Research, Vol. 1015, No. 1-2Characterization of Wide Dynamic Range Neurons in the Deep Dorsal Horn of the Spinal Cord in Preprotachykinin-A Null Mice In VivoWilliam J. Martin, YuQing Cao, and Allan I. Basbaum1 May 2004 | Journal of Neurophysiology, Vol. 91, No. 5Molecular mechanism of changes in the morphine-induced pharmacological actions under chronic pain-like state: Suppression of dopaminergic transmission in the brainLife Sciences, Vol. 74, No. 21Neural basis of sensation in intact and injured corneasExperimental Eye Research, Vol. 78, No. 3A quantitative somatosensory testing of pain threshold in individuals with mental retardationPain, Vol. 108, No. 1The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-d-aspartate receptorGastroenterology, Vol. 126, No. 3Spinal nerve injury increases the percentage of cold-responsive DRG neuronsNeuroReport, Vol. 15, No. 3Biomechanics of musculoskeletal pain: dynamics of the neuromatrixJournal of Electromyography and Kinesiology, Vol. 14, No. 1Responses of C-fiber low threshold mechanoreceptors and nociceptors to cold were facilitated in rats persistently inflamed and hypersensitive to coldNeuroscience Research, Vol. 47, No. 4Spatial summation of pressure pain: effect of body regionPain, Vol. 106, No. 3Overexpression and purification of the vanilloid receptor in yeast (Saccharomyces cerevisiae)Biochemical and Biophysical Research Communications, Vol. 310, No. 1Comment on, Pain elicited by blunt pressure: neurobiological basis and clinical relevance. Treede et al., (Pain 98 (2002) 235)Pain, Vol. 104, No. 3Lessons from peppers and peppermint: the molecular logic of thermosensationCurrent Opinion in Neurobiology, Vol. 13, No. 4Quantifying sensation: "Look Back in Allodynia"9 January 2012 | European Journal of Pain, Vol. 7, No. 4TRPM8 mRNA Is Expressed in a Subset of Cold-Responsive Trigeminal Neurons From RatMichele L. Nealen, Michael S. Gold, Paul D. Thut, and Michael J. Caterina1 July 2003 | Journal of Neurophysiology, Vol. 90, No. 1Cold transduction in rat trigeminal ganglia neurons in vitroNeuroscience, Vol. 119, No. 4painless, a Drosophila Gene Essential for NociceptionCell, Vol. 113, No. 2Receptive Field Properties of Unmyelinated Tactile Afferents in the Human SkinJohan Wessberg, Håkan Olausson, Katarina Wiklund Fernström, and Åke B. Vallbo1 March 2003 | Journal of Neurophysiology, Vol. 89, No. 3Factors influencing pricking pain threshold using a CO 2 laser2 January 2003 | Physiological Measurement, Vol. 24, No. 1Sympathetic sudomotor skin responses induced by laser stimuli in normal human subjectsNeuroscience Letters, Vol. 334, No. 2A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction22 July 2004 | The Journal of Physiology, Vol. 545, No. 2Tissue glucose level modulates the mechanical responses of cutaneous nociceptors in streptozotocin-diabetic rats but not normal rats in vitroPain, Vol. 99, No. 3Halothane Suppression of Spinal Sensory Neuronal Responses to Noxious Peripheral Stimuli Is Mediated, in Part, by Both GABAA and Glycine Receptor SystemsAnesthesiology, Vol. 97, No. 2Sensitization to Mechanical Stimulation by Inflammatory Mediators and by Mild Burn in Canine Visceral Nociceptors In VitroHisashi Koda, and Kazue Mizumura1 April 2002 | Journal of Neurophysiology, Vol. 87, No. 4Preferential Block of Small Myelinated Sensory and Motor Fibers by LidocaineAnesthesiology, Vol. 95, No. 6Quantitative Response Characteristics of Thermoreceptive and Nociceptive Lamina I Spinothalamic Neurons in the CatA. D. Craig, K. Krout, and D. Andrew1 September 2001 | Journal of Neurophysiology, Vol. 86, No. 3Sensory experiences in humans and single-unit activity in cats evoked by polymodal stimulation of the cornea5 August 2004 | The Journal of Physiology, Vol. 534, No. 2Response Properties of Mechanoreceptors and Nociceptors in Mouse Glabrous Skin: An In Vivo StudyDavid M. Cain, Sergey G. Khasabov, and Donald A. Simone1 April 2001 | Journal of Neurophysiology, Vol. 85, No. 4Axotomy- and Autotomy-Induced Changes in the Excitability of Rat Dorsal Root Ganglion NeuronsFuad A. Abdulla, and Peter A. Smith1 February 2001 | Journal of Neurophysiology, Vol. 85, No. 2Axotomy- and Autotomy-Induced Changes in Ca2+and K+ Channel Currents of Rat Dorsal Root Ganglion NeuronsFuad A. Abdulla, and Peter A. Smith1 February 2001 | Journal of Neurophysiology, Vol. 85, No. 2Sensory Fibers of the Pelvic Nerve Innervating the Rat's Urinary BladderV. K. Shea, R. Cai, B. Crepps, J. L. Mason, and E. R. Perl1 October 2000 | Journal of Neurophysiology, Vol. 84, No. 4Trigeminohypothalamic and Reticulohypothalamic Tract Neurons in the Upper Cervical Spinal Cord and Caudal Medulla of the RatAmy Malick, Rew M. Strassman, and Rami Burstein1 October 2000 | Journal of Neurophysiology, Vol. 84, No. 4Responses of nerve fibres of the rat saphenous nerve neuroma to mechanical and chemical stimulation: an in vitro study13 August 2004 | The Journal of Physiology, Vol. 527, No. 2Response Properties and Organization of Nociceptive Neurons in Area 1 of Monkey Primary Somatosensory CortexDan R. Kenshalo, Koichi Iwata, Maurice Sholas, and David A. Thomas1 August 2000 | Journal of Neurophysiology, Vol. 84, No. 2Response of Cutaneous A- and C-Fiber Nociceptors in the Monkey to Controlled-Force StimuliR. M. Slugg, R. A. Meyer, and J. N. Campbell1 April 2000 | Journal of Neurophysiology, Vol. 83, No. 4Changes in somatic action potential shape in guinea-pig nociceptive primary afferent neurones during inflammation in vivo7 September 2004 | The Journal of Physiology, Vol. 520, No. 2Unmyelinated Afferents Constitute a Second System Coding Tactile Stimuli of the Human Hairy SkinÅ. B. Vallbo, H. Olausson, and J. Wessberg1 June 1999 | Journal of Neurophysiology, Vol. 81, No. 6Modality-specific hyper-responsivity of regenerated cat cutaneous nociceptors8 September 2004 | The Journal of Physiology, Vol. 516, No. 3Association of somatic action potential shape with sensory receptive properties in guinea-pig dorsal root ganglion neurones22 September 2004 | The Journal of Physiology, Vol. 513, No. 3Mechanosensitive Pelvic Nerve Afferent Fibers Innervating the Colon of the Rat are Polymodal in CharacterX. Su, and G. F. Gebhart1 November 1998 | Journal of Neurophysiology, Vol. 80, No. 5The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing StimuliNeuron, Vol. 21, No. 3Varicosis, Aesthetics, and Pain30 November 2016 | The American Journal of Cosmetic Surgery, Vol. 15, No. 2Attenuated response of renal mechanoreceptors to volume expansion in chronically hypoxic ratsChiang-Ting Chien, Tsu-Ching Fu, Ming-Shiou Wu, and Chau-Fong Chen1 November 1997 | American Journal of Physiology-Renal Physiology, Vol. 273, No. 5Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig30 September 2004 | The Journal of Physiology, Vol. 505, No. 1Receptive Properties of Mouse Sensory Neurons Innervating Hairy SkinMartin Koltzenburg, Cheryl L. Stucky, and Gary R. Lewin1 October 1997 | Journal of Neurophysiology, Vol. 78, No. 4Tensile and Compressive Responses of Nociceptors in Rat Hairy SkinPartap S. Khalsa, Robert H. Lamotte, and Peter Grigg1 July 1997 | Journal of Neurophysiology, Vol. 78, No. 1Warm-Sensitive Afferent Splanchnic C-Fiber Units In VitroDavid W. Adelson, Jen Yu Wei, and Lawrence Kruger1 June 1997 | Journal of Neurophysiology, Vol. 77, No. 6Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonistsBrain Research, Vol. 759, No. 2Responses of Cutaneous A-Fiber Nociceptors to Noxious ColdDonald A. Simone, and Keith C. Kajander1 April 1997 | Journal of Neurophysiology, Vol. 77, No. 4The progressive tactile hyperalgesia induced by peripheral inflammation is nerve growth factor dependentNeuroReport, Vol. 8, No. 4Effects of bupivacaine infiltration on beta-endorphin and cortisol release and postoperative pain following inguinal herniorrhaphy in children21 September 2013 | Pediatric Surgery International, Vol. 11, No. 1Nociceptive neurones in rat superior colliculusExperimental Brain Research, Vol. 109, No. 2Evidence for central summation of C and Aδ nociceptive activity in manPain, Vol. 59, No. 2Characterization of the foot withdrawal response to noxious radiant heat in the ratPain, Vol. 59, No. 1C mechanical nociceptive neurons in the crotaline trigeminal gangliaNeuroscience Letters, Vol. 179, No. 1-2Norepinephrine excitation of cutaneous nociceptors in adjuvant-induced inflamed rats does not depend on sympathetic neuronsNeuroscience Letters, Vol. 177, No. 1-2Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activationPain, Vol. 58, No. 2Possible involvement of the EP2 receptor subtype in PGE2-induced enhancement of the heat response of nociceptorsNeuroscience Letters, Vol. 175, No. 1-2The effect of trans-ACPD, a metabotropic excitatory amino acid receptor agonist, on the responses of primate spinothalamic tract neuronsPain, Vol. 56, No. 3Intense cold noxious stimulation of the rat hindpaw induces c-fos expression in lumbar spinal cord neuronsNeuroscience, Vol. 59, No. 2Involvement of EP3 subtype of prostaglandin E receptors in PGE2-induced enhancement of the bradykinin response of nociceptorsBrain Research, Vol. 632, No. 1-2Adrenergic excitation of cutaneous nociceptors in chronically inflamed ratsNeuroscience Letters, Vol. 164, No. 1-2Prostaglandin E2-induced sensitization of the heat response of canine visceral polymodal receptors in vitroNeuroscience Letters, Vol. 161, No. 1Afferent and spinal mechanisms of joint painPain, Vol. 55, No. 1Nociception from skeletal muscle in relation to clinical muscle painPain, Vol. 54, No. 3Functional development of central nervous system in the rat: Ontogeny of nociceptive thresholdsPhysiology & Behavior, Vol. 54, No. 2Development of secondary hyperalgesia following non-painful thermal stimulation of the skin: a psychophysical study in manPain, Vol. 54, No. 2Capsaicin-induced activation of fine afferent fibres from rat skin in vitroNeuroscience, Vol. 55, No. 2The roles of spatial recruitment and discharge frequency in spinal cord coding of pain: a combined electrophysiological and imaging investigationPain, Vol. 53, No. 3A stimulator for studies of mechanical nociception based upon a commercially available translation tableJournal of Neuroscience Methods, Vol. 47, No. 3Comparison of intradermal and subcutaneous hyperalgesic effects of inflammatory mediators in the ratNeuroscience Letters, Vol. 153, No. 2Emerging relationships between cytochemical properties and sensory modality transmission in primary sensory neuronsBrain Research Bulletin, Vol. 30, No. 3-4Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathyBrain Research, Vol. 598, No. 1-2Responses of trigeminal subnucleus interpolaris neurons to afferent inputs from deep oral structuresBrain Research Bulletin, Vol. 29, No. 6Contribution of protein kinase C to central sensitization and persistent pain following tissue injuryNeuroscience Letters, Vol. 140, No. 2Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathyBrain Research, Vol. 576, No. 2Peripheral and central mechanisms of cutaneous hyperalgesiaProgress in Neurobiology, Vol. 38, No. 4Sensitizing effects of leukotriene B4 on intradental primary afferentsPain, Vol. 49, No. 1Arimary afferent interactions: Analysis of calcitonin gene-related peptide-immunoreactive terminals in contact with unlabeled and GABA-immunoreactive profiles in the monkey dorsal hornNeuroscience, Vol. 47, No. 4Blood flow increases in the skin of the anaesthetized rat that follow antidromic sensory nerve stimulation and strong mechanical stimulationNeuroscience Letters, Vol. 137, No. 2Identification and characterization of afferent periodontal C fibres in the catPain, Vol. 48, No. 3Mechanically insensitive afferents (MIAs) in cutaneous nerves of monkeyBrain Research, Vol. 561, No. 2Changes in lectin, GAP-43 and neuropeptide staining in the rat superficial dorsal horn following experimental peripheral neuropathyNeuroscience Letters, Vol. 131, No. 2Hyperperfusion of the rat brain during reflex hypertension induced by sudden lowering of the cutaneous temperatureJournal of the Autonomic Nervous System, Vol. 35, No. 2The acute effects of amputation on peripheral trigeminal afferents in Gallus gallus var domesticusPain, Vol. 46, No. 1Reflex changes in thermogenesis in the interscapular brown adipose tissue in response to thermal stimulation of the skin via sympathetic efferent nerves in anesthetized ratsJournal of the Autonomic Nervous System, Vol. 33, No. 1Temporal characteristics of capsaicin sensitization and desensitization on the tonguePhysiology & Behavior, Vol. 49, No. 3'Silent' nociceptors in the skinTrends in Neurosciences, Vol. 14, No. 3The induction and maintenance of central sensitization is dependent on N-methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity statesPain, Vol. 44, No. 3Common patterns of plasticity contributing to nociceptive sensitization in mammals and AplysiaTrends in Neurosciences, Vol. 14, No. 2Electrophysiologic recording and thermodynamic modeling demonstrate that helium-neon laser irradiation does not affect peripheral Aδ- or C-fiber nociceptorsPain, Vol. 43, No. 2Novel classes of nociceptors: beyond SherringtonTrends in Neurosciences, Vol. 13, No. 6Further evidence for 'pain-related' behaviours in a model of unilateral peripheral mononeuropathyPain, Vol. 41, No. 2Inhibition of nociceptive responses of dorsal horn neurones in the cat spinal cord by ohmefentanyl, a preferring μ opioid receptor antagonistNeuroscience Letters, Vol. 112, No. 1Convergence patterns of afferent information from the temporomandibular joint and masseter muscle in the trigeminal subnucleus caudalisBrain Research Bulletin, Vol. 24, No. 4Pain: Theory, Anatomy, and PhysiologyCritical Care Clinics, Vol. 6, No. 2Carrageenan inflammation increases bradykinin sensitivity of rat cutaneous nociceptorsNeuroscience Letters, Vol. 111, No. 1-2Leukotriene B4 induced decrease in mechanical and thermal thresholds of C-fiber mechanonociceptors in rat hairy skinBrain Research, Vol. 509, No. 2Calcitonin gene-related peptide containing primary afferent fibers synapse on primate spinothalamic tract cellsNeuroscience Letters, Vol. 109, No. 1-2Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: Comparison with spinal morphineNeuroscience, Vol. 34, No. 3Dynorphin A(1–8) immunoreactive cell bodies, dendrites and terminals are postsynaptic to calcitonin gene-related peptide primary afferent terminals in the monkey dorsal hornBrain Research, Vol. 504, No. 1Sympathetic facilitation of sustained discharges of polymodal nociceptorsPain, Vol. 38, No. 1Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situNeuroscience, Vol. 30, No. 1Increase in extracellular potassium level in rat spinal dorsal horn induced by noxious stimulation and peripheral injuryBrain Research, Vol. 458, No. 1Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the catBrain Research, Vol. 451, No. 1-2Responses to heat of C-fiber nociceptors in monkey are altered by injury in the receptive field but not by adjacent injuryPain, Vol. 32, No. 3Antidromic nerve stimulation in monkey does not sensitize unmyelinated nociceptors to heatBrain Research, Vol. 441, No. 1-2Long-lasting neuronal activity in rat dorsal horn evoked by impulses in cutaneous C fibres during noxious mechanical stimulationBrain Research, Vol. 439, No. 1-2Quantitative relationship between the stimulus intensity and the response magnitude in the tail flick reflexPhysiology & Behavior, Vol. 43, No. 1Effects of repeated noxious thermal stimuli on the responses of neurons in the lateral cervical nucleus of cats: evidence for an input from A-nociceptors to the spinocervicothalamic pathwayBrain Research, Vol. 436, No. 2Dorsal horn (convergent) neurones in the intact anaesthetized arthritic rat. II. Heterotopic inhibitory influencesPain, Vol. 31, No. 3Activation of unmyelinated afferents in chronically lesioned nerves by adrenaline and excitation of sympathetic efferents in the catNeuroscience Letters, Vol. 82, No. 1Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbsNeuroscience, Vol. 22, No. 2Response to an itch-producing substance in cat. I. Cutaneous receptor populations with myelinated axonsBrain Research, Vol. 413, No. 1Response to an itch-producing substance in cat. II. Cutaneous receptor populations with unmyelinated axonsBrain Research, Vol. 413, No. 1The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the ratPain, Vol. 29, No. 3Thermally potentiated responses to algesic substances of visceral nociceptorsPain, Vol. 28, No. 2A quantitative study on the tail flick test in the ratPhysiology & Behavior, Vol. 39, No. 2Dorsal horn (convergent) neurones in the intact anaesthetized arthritic rat. I. Segmental excitatory influencesPain, Vol. 28, No. 1Prolonged discharge of wide-dynamic-range spinal neurons evoked by formaldehyde injected in their cutaneous receptive fieldsExperimental Neurology, Vol. 93, No. 1Presynaptic effect of clonidine on unmyelinated afferent fibers in the spinal cord of the catNeuroscience Letters, Vol. 64, No. 3A hypothesis on the physiological basis for causalgia and related painsPain, Vol. 24, No. 3Dorsal column postsynaptic neurons in the cat are excited by myelinated nociceptorsBrain Research, Vol. 364, No. 2Hyperalgesia following ischaemia of the rat's tailPain, Vol. 24, No. 2The electrophysiological and morphological characteristics of feline dorsal root ganglion cellsBrain Research, Vol. 362, No. 1Menthol inhibits the perception of warmthPhysiology & Behavior, Vol. 38, No. 6Selective reduction of second pain sensations by systemic morphine in humansPain, Vol. 24, No. 1Leukotriene B4 produces hyperalgesia in humansProstaglandins, Vol. 30, No. 5Response of cat skin mechanothermal nociceptors to cold stimulationBrain Research Bulletin, Vol. 15, No. 5A differential effect of naloxone on transmission of impulses in primary afferents to ventral roots and ascending spinal tractsBrain Research, Vol. 344, No. 2Injury-induced plasticity of the flexor reflex in chronic decerebrate ratsNeuroscience, Vol. 16, No. 2Sympathetic activation of unmyelinated mechanoreceptors in cat skinBrain Research, Vol. 339, No. 1Electrophysiologically recorded C-fiber reflexes in intact and acute decerebrate-spinal cats: Absence of nalckone facilitation in intact catsNeuropharmacology, Vol. 24, No. 6Neuropeptides in physiologically identified mammalian sensory neuronesNeuroscience Letters, Vol. 56, No. 3The encoding of thermal stimuli applied to the tail of the rat by lowering the excitability of trigeminal convergent neuronesBrain Research, Vol. 330, No. 2Influence of the rate of temperature change on thermal thresholds in manExperimental Neurology, Vol. 87, No. 3Sting like a bee! The ionophoric properties of melittinTrends in Biochemical Sciences, Vol. 10, No. 3Postsynaptic dorsal column pathway of the rat. II. Evidence against an important role in nociceptionBrain Research, Vol. 326, No. 2Opiate and histamine H1 receptors are present on some substance P-containing dorsal root ganglion cellsNeuroscience Letters, Vol. 53, No. 1Responses of single cutaneous fibers to noxious thermal pulse stimulation of cat upper hind limbPain, Vol. 21, No. 1Computer separation of multi-unit neuroelectric data: a reviewJournal of Neuroscience Methods, Vol. 12, No. 2Discharge pattern of afferent fibers from a neuromaPain, Vol. 20, No. 4Abnormal activity of polymodal receptors induced by clioquinol (5-chloro-7-iodo-8-hydroxyquinoline)Brain Research, Vol. 310, No. 1A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal gray matter in the rat. I. The production of behavioral side effects together with analgesiaBrain Research, Vol. 306, No. 1-2Receptive fields of rat lamina 1 projection cells move to incorporate a nearby region of injuryPain, Vol. 19, No. 3Suppression of C-fibre discharges upon repeated heat stimulation may explain characteristics of concomitant pain sensationsBrain Research, Vol. 302, No. 2Cutaneous Receptors and their Sensory Functions1 February 1984 | Journal of Hand Surgery, Vol. 9, No. 1Basic neurobiologic mechanisms of pain and analgesiaThe American Journal of Medicine, Vol. 75, No. 5Temperature dependency of the chemical responses of the polymodal receptor units in vitroBrain Research, Vol. 278, No. 1-2Painful sensation induced by a thermal cutaneous stimulusPain, Vol. 17, No. 2Lateral reticular regions and the descending control of dorsal horn neurones of the cat: Selective inhibition by electrical stimulationBrain Research, Vol. 275, No. 1Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humansBrain Research, Vol. 274, No. 1Do convergent neurones in the spinal dorsal horn discriminate nociceptive from non-nociceptive information?Pain, Vol. 17, No. 1Parallel processing of somatosensory information: A theoryBrain Research Reviews, Vol. 6, No. 1Altered excitability of afferent C-fibres of the rat distal to a nerve site exposed to capsaicinNeuroscience Letters, Vol. 38, No. 3Latency to detection of first painBrain Research, Vol. 266, No. 2Unmyelinated nociceptive units in two skin areas of the ratBrain Research, Vol. 267, No. 1The effect of capsaicin application to a peripheral nerve on impulse conduction in functionally identified afferent nerve fibresBrain Research, Vol. 265, No. 2Facilitatory interaction between cutaneous afferents from low threshold mechanoreceptors and nociceptors in segmental reflex pathways to α-motoneuronsBrain Research, Vol. 260, No. 1Behavioral test of tolerance for aversive mechanical stimuli in sympathectomized catsPain, Vol. 15, No. 1Periaqueductal grey stimulation: an association between selective inhibition of dorsal horn neurones and changes in peripheral circulationPain, Vol. 15, No. 1Disturbances of thermoregulation induced by capsaicinJournal of Thermal Biology, Vol. 8, No. 1-2The effect of capsaicin on the response characteri

Referência(s)