N-methyl-D-aspartic acid receptor structure and function
1994; American Physiological Society; Volume: 74; Issue: 3 Linguagem: Inglês
10.1152/physrev.1994.74.3.723
ISSN1522-1210
AutoresChristopher J. McBain, Moriz Mayer,
Tópico(s)Anesthesia and Neurotoxicity Research
ResumoarticleN-methyl-D-aspartic acid receptor structure and functionC. J. McBain, and M. L. MayerC. J. McBainLaboratory of Cellular and Molecular Neurophysiology, NationalInstitute of Child Health and Human Development, National Institutes ofHealth, Bethesda, Maryland., and M. L. MayerLaboratory of Cellular and Molecular Neurophysiology, NationalInstitute of Child Health and Human Development, National Institutes ofHealth, Bethesda, Maryland.Published Online:01 Jul 1994https://doi.org/10.1152/physrev.1994.74.3.723MoreSectionsPDF (11 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Download PDF FiguresReferencesRelatedInformation Cited ByNeurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors24 August 2018 | Translational Psychiatry, Vol. 8, No. 1Role of copper in depression. 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Berger1 October 2004 | Journal of Neurophysiology, Vol. 92, No. 4Amino terminal domain regulation of NMDA receptor functionEuropean Journal of Pharmacology, Vol. 500, No. 1-3Opiate physical dependence and N-methyl-d-aspartate receptorsEuropean Journal of Pharmacology, Vol. 500, No. 1-3Molecular Mechanisms Underlying Emotional Learning and Memory in the Lateral AmygdalaNeuron, Vol. 44, No. 1The principal features and mechanisms of dopamine modulation in the prefrontal cortexProgress in Neurobiology, Vol. 74, No. 1Energy metabolism in mammalian brain during developmentProgress in Neurobiology, Vol. 73, No. 6Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposalTrends in Neurosciences, Vol. 27, No. 7IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cellsNeuropharmacology, Vol. 46, No. 8The NMDA Receptor Gating Machine: Lessons from Single Channels29 June 2016 | The Neuroscientist, Vol. 10, No. 3Zn 2+ Inhibits Glycine Transport by Glycine Transporter Subtype 1b18 March 2004 | Journal of Biological Chemistry, Vol. 279, No. 22Modal gating of NMDA receptorsTrends in Neurosciences, Vol. 27, No. 5Schaffer collateral and perforant path inputs activate different subtypes of NMDA receptors on the same CA1 pyramidal cellBritish Journal of Pharmacology, Vol. 142, No. 2Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 26 April 2004 | Proceedings of the National Academy of Sciences, Vol. 101, No. 16Bidirectional Regulation of Neuronal Nitric-oxide Synthase Phosphorylation at Serine 847 by the N -Methyl-d-aspartate Receptor13 January 2004 | Journal of Biological Chemistry, Vol. 279, No. 14Temporal dynamics of NMDA receptor-induced changes in spine morphology and AMPA receptor recruitment to spinesBiochemical and Biophysical Research Communications, Vol. 316, No. 2Src kinases: a hub for NMDA receptor regulation1 April 2004 | Nature Reviews Neuroscience, Vol. 5, No. 4The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expressionEpilepsy Research, Vol. 59, No. 1The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCsEpilepsy Research, Vol. 59, No. 1Topical Review: Activated Remodeling and N-Methyl-D-Aspartate (NMDA) Receptors in Cortical Dysplasia2 July 2016 | Journal of Child Neurology, Vol. 19, No. 3Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathologyNeurobiology of Disease, Vol. 15, No. 1Intracellular spermine decreases open probability ofN-methyl-d-aspartate receptor channelsNeuroscience, Vol. 125, No. 4Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insultsNeuroRX, Vol. 1, No. 1Failure to form a stable topographic map during optic nerve regeneration: abnormal activity-dependent mechanismsExperimental Neurology, Vol. 184, No. 2Dynorphin A inhibits NMDA receptors through a pH-dependent mechanismMolecular and Cellular Neuroscience, Vol. 24, No. 3Glutamatergic Transmission in Opiate and Alcohol DependenceAnnals of the New York Academy of Sciences, Vol. 1003, No. 1Effect of the NR3 subunit on ethanol inhibition of recombinant NMDA receptorsBrain Research, Vol. 987, No. 1Characterization of modes of release of amino acids in the ischemic/reperfused rat cerebral cortexNeurochemistry International, Vol. 43, No. 4-5Lithium reduced N-methyl-d-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemiaNeuroscience Letters, Vol. 348, No. 3Comparison of the effect of glutamate receptor modulators in the 6 Hz and maximal electroshock seizure modelsEpilepsy Research, Vol. 56, No. 1Increased susceptibility to LTP generation and changes in NMDA-NR1 and -NR2B subunits mRNA expression in rat hippocampus after MCH administrationPeptides, Vol. 24, No. 9The Amygdaloid Complex: Anatomy and PhysiologyP. SAH, E. S. L. FABER, M. LOPEZ DE ARMENTIA, and J. POWER1 July 2003 | Physiological Reviews, Vol. 83, No. 3Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventionsEuropean Journal of Medicinal Chemistry, Vol. 38, No. 7-8Dark-rearing decreases NR2A N-methyl-d-aspartate receptor subunit in all visual cortical layersNeuroscience, Vol. 119, No. 4Postsynaptic modulation of AMPA- and NMDA-receptor currents by Group III metabotropic glutamate receptors in rat nucleus accumbensBrain Research, Vol. 976, No. 1Modal gating of NMDA receptors and the shape of their synaptic response7 April 2003 | Nature Neuroscience, Vol. 6, No. 5Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity23 April 2003 | European Journal of Neuroscience, Vol. 17, No. 7Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibitionNeuropharmacology, Vol. 44, No. 3Glycine Tranporter-1 Blockade Potentiates NMDA-Mediated Responses in Rat Prefrontal Cortical Neurons In Vitro and In VivoLong Chen, Mark Muhlhauser, and Charles R. Yang1 February 2003 | Journal of Neurophysiology, Vol. 89, No. 2Transient neonatal expression of NR2B/2D subunit mRNAs of the N-methyl-d-aspartate receptor in the parasympathetic preganglionic neurons in the rat spinal cordDevelopmental Brain Research, Vol. 140, No. 2Signaling molecules and receptor transduction cascades that regulate nmda receptor-mediated synaptic transmissionThe N-methyl-d-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implicationsPharmacology & Therapeutics, Vol. 97, No. 1Synthesis and Structure–Activity Relationship Studies of Novel 2-Diarylethyl Substituted (2-Carboxycycloprop-1-yl)glycines as High-Affinity Group II Metabotropic Glutamate Receptor LigandsBioorganic & Medicinal Chemistry, Vol. 11, No. 2A Site in the Fourth Membrane-associated Domain of the N-Methyl-d-aspartate Receptor Regulates Desensitization and Ion Channel GatingJournal of Biological Chemistry, Vol. 278, No. 1Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line18 December 2002 | European Journal of Neuroscience, Vol. 16, No. 12Cysteine regulation of protein function – as exemplified by NMDA-receptor modulationTrends in Neurosciences, Vol. 25, No. 9A D2 Class Dopamine Receptor Transactivates a Receptor Tyrosine Kinase to Inhibit NMDA Receptor TransmissionNeuron, Vol. 35, No. 6Neonatal sex steroids affect ventilatory responses to aspartic acid and NMDA receptor subunit 1 in ratsYijiang Shi, and Evelyn H. Schlenker1 June 2002 | Journal of Applied Physiology, Vol. 92, No. 6Characterization and Comparison of the NR3A Subunit of the NMDA Receptor in Recombinant Systems and Primary Cortical NeuronsYasnory F. Sasaki*, Thomas Rothe*, Louis S. Premkumar, Saumya Das, Jiankun Cui, Maria V. Talantova, Hon-Kit Wong, Xiandi Gong, Shing Fai Chan, Dongxian Zhang, Nobuki Nakanishi, Nikolaus J. Sucher, and Stuart A. Lipton1 April 2002 | Journal of Neurophysiology, Vol. 87, No. 4Distinct NMDA Receptors Provide Differential Modes of Transmission at Mossy Fiber-Interneuron SynapsesNeuron, Vol. 33, No. 6Tyrosine Phosphatase STEP Is a Tonic Brake on Induction of Long-Term PotentiationNeuron, Vol. 34, No. 1Energy utilization in the ischemic/reperfused brainChapter 3 Cellular calcium dynamicsBarrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit CompositionNeuron, Vol. 32, No. 4NMDA Antagonists in the Superior Colliculus Prevent Developmental Plasticity But Not Visual Transmission or Map CompressionL. Huang, and S. L. Pallas1 September 2001 | Journal of Neurophysiology, Vol. 86, No. 3Glutamate-Mediated Extrasynaptic InhibitionNeuron, Vol. 31, No. 6Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A6 August 2001 | Nature Neuroscience, Vol. 4, No. 9Positive Allosteric Modulators of AMPA Receptors Reduce Proton-Induced Receptor Desensitization in Rat Hippocampal NeuronsSaobo Lei, Beverley A. Orser, Gregory R. L. Thatcher, James N. Reynolds, and John F. MacDonald1 May 2001 | Journal of Neurophysiology, Vol. 85, No. 5Enhanced NMDA receptor activity in retinal inputs to the rat suprachiasmatic nucleus during the subjective night5 August 2004 | The Journal of Physiology, Vol. 532, No. 1CAKβ/Pyk2 Kinase Is a Signaling Link for Induction of Long-Term Potentiation in CA1 HippocampusNeuron, Vol. 29, No. 2Visual Experience and Deprivation Bidirectionally Modify the Composition and Function of NMDA Receptors in Visual CortexNeuron, Vol. 29, No. 1The Role of RNA Editing of Kainate Receptors in Synaptic Plasticity and SeizuresNeuron, Vol. 29, No. 1Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal NeuronsNeuron, Vol. 29, No. 1New Developments in Drug Dependence Studies. Mechanisms of morphine-induced rewarding effect. Involvement of NMDA receptor subunits.Folia Pharmacologica Japonica, Vol. 117, No. 1[ 3 H](+)MK801 Radioligand Binding Assay at the N -Methyl- D -Aspartate Receptor1 May 2001 | Current Protocols in Pharmacology, Vol. 11, No. 1Lesion-induced changes in NMDA receptor subunit mRNA expression in rat visual cortexNeuroReport, Vol. 11, No. 18Competitive Inhibition of NMDA Receptor–Mediated Currents by Extracellular Calcium ChelatorsNansheng Chen, Timothy H. Murphy, and Lynn A. Raymond1 August 2000 | Journal of Neurophysiology, Vol. 84, No. 2Light-Evoked Excitatory Synaptic Currents of X-Type Retinal Ganglion CellsEthan D. Cohen1 June 2000 | Journal of Neurophysiology, Vol. 83, No. 6Developmental regulation of subunit composition of extrasynaptic NMDA receptors in neocortical neuronesNeuroReport, Vol. 11, No. 6Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum13 August 2004 | The Journal of Physiology, Vol. 524, No. 1Enhancement of NMDA receptor‐mediated currents by light in rat neurones in vitro1 April 2000 | The Journal of Physiology, Vol. 524, No. 2Exon 5 and Spermine Regulate Deactivation of NMDA Receptor SubtypesGavin Rumbaugh, Kate Prybylowski, Jian Feng Wang, and Stefano Vicini1 March 2000 | Journal of Neurophysiology, Vol. 83, No. 3Four Residues of the Extracellular N-Terminal Domain of the NR2A Subunit Control High-Affinity Zn2+ Binding to NMDA ReceptorsNeuron, Vol. 25, No. 3Development of Glutamatergic Synaptic Activity in Cultured Spinal NeuronsAntoine Robert, James R. Howe, and Stephen G. Waxman1 February 2000 | Journal of Neurophysiology, Vol. 83, No. 2Fast NMDA Receptor–Mediated Synaptic Currents in Neurons From Mice Lacking the ε2 (NR2B) SubunitKenneth R. Tovar, Kathleen Sprouffske, and Gary L. Westbrook1 January 2000 | Journal of Neurophysiology, Vol. 83, No. 1Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell deathMuyiwa Gbadegesin, Stefano Vicini, Sandra J. Hewett, David A. Wink, Michael Espey, Ryszard M. Pluta, and Carol A. 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Berger, Stéphane Dieudonné, and Philippe Ascher1 December 1998 | Journal of Neurophysiology, Vol. 80, No. 6Heterogeneity of homomeric GluR5 kainate receptor desensitization expressed in HEK293 cells22 September 2004 | The Journal of Physiology, Vol. 513, No. 3The Role of the N-Methyl-D-Aspartic Acid Receptor in the Relaxant Effect of Ketamine on Tracheal Smooth MuscleAnesthesia & Analgesia, Vol. 87, No. 6Ascorbate modulates glutamate-induced excitations of striatal neuronsBrain Research, Vol. 812, No. 1-2Open Channel Block and Alteration of N -Methyl- d -Aspartic Acid Receptor Gating by an Analog of PhencyclidineBiophysical Journal, Vol. 75, No. 4Multiple sites of action of neomycin, Mg 2+ and spermine on the NMDA receptors of rat hippocampal CA1 pyramidal neurones22 September 2004 | The Journal of Physiology, Vol. 512, No. 1Interaction of memantine and amantadine with agonist-unbound NMDA-receptor channels in acutely isolated rat hippocampal neurons22 September 2004 | The Journal of Physiology, Vol. 512, No. 1Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABPNeuron, Vol. 21, No. 3Calmodulin Mediates Calcium-Dependent Inactivation of N-Methyl-D-Aspartate ReceptorsNeuron, Vol. 21, No. 2pH modulation of Ca 2+ responses and a Ca 2+ -dependent K + channel in cultured rat hippocampal neurones22 September 2004 | The Journal of Physiology, Vol. 511, No. 1Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3ANature, Vol. 393, No. 6683Regulation of kinetic and pharmacological properties of synaptic NMDA receptors depends on presynaptic exocytosis in rat hippocampal neurones22 September 2004 | The Journal of Physiology, Vol. 508, No. 2Two Blocking Sites of Amino-Adamantane Derivatives in Open N -Methyl- d -Aspartate ChannelsBiophysical Journal, Vol. 74, No. 3Functional and Pharmacological Differences Between RecombinantN-Methyl-d-Aspartate ReceptorsStefano Vicini, Jian Feng Wang, Jin Hong Li, Wei Jian Zhu, Yue Hua Wang, Jian Hong Luo, Barry B. Wolfe, and Dennis R. Grayson1 February 1998 | Journal of Neurophysiology, Vol. 79, No. 2N-Terminal Domains in the NR2 Subunit Control Desensitization of NMDA ReceptorsNeuron, Vol. 20, No. 2Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons22 September 2004 | The Journal of Physiology, Vol. 507, No. 1The Role of Glutamate in Physical Dependence on Opioids.The Japanese Journal of Pharmacology, Vol. 76, No. 1Metabotropic Glutamate Receptors Regulate N-Methyl-d-Aspartate–Mediated Synaptic Transmission in Nucleus AccumbensGilles Martin, Zhiguo Nie, and George R. Siggins1 December 1997 | Journal of Neurophysiology, Vol. 78, No. 6Presynaptic exocytosis regulates NR2A mRNA expression in cultured neocortical neuronesNeuroReport, Vol. 8, No. 17Neurotrophin Modulation of NMDA Receptors in Cultured Murine and Isolated Rat NeuronsC. R. Jarvis, Z.-G. Xiong, J. R. Plant, D. Churchill, W.-Y. Lu, B. A. Macvicar, and J. F. Macdonald1 November 1997 | Journal of Neurophysiology, Vol. 78, No. 5A Fast Synaptic Potential Mediated by NMDA and Non-NMDA ReceptorsLaura R. Wolszon, Alberto E. Pereda, and Donald S. Faber1 November 1997 | Journal of Neurophysiology, Vol. 78, No. 5Topical Review: Glutamate in Neurologic Diseases2 July 2016 | Journal of Child Neurology, Vol. 12, No. 8Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal NeuronsNeuron, Vol. 19, No. 4Prolonged Physiological Entrapment of Glutamate in the Synaptic Cleft of Cerebellar Unipolar Brush CellsGregory A. Kinney, Linda S. Overstreet, and N. Traverse Slater1 September 1997 | Journal of Neurophysiology, Vol. 78, No. 3Involvement of cAMP-Dependent Protein Kinase in μ-Opioid Modulation of NMDA-Mediated Synaptic CurrentsCui-Wei Xie, and Darrell V. Lewis1 August 1997 | Journal of Neurophysiology, Vol. 78, No. 2Reduced NMDA receptor sensitivity may underlie the resistance of subpopulations of PVN neurons to excitotoxicityNeuroReport, Vol. 8, No. 9Multiple Mechanisms of Ketamine Blockade of N-methyl-D-aspartate ReceptorsAnesthesiology, Vol. 86, No. 4AII amacrine cells express functional NMDA receptorsNeuroReport, Vol. 8, No. 5The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial MemoryCell, Vol. 87, No. 7Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortexBrain Research, Vol. 730, No. 1-2Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestionMolecular Brain Research, Vol. 40, No. 1NMDA-but not AMPA-receptor antagonists augment scopolamine-induced spatial cognitive deficit of rats in a radial maze taskBrain Research, Vol. 725, No. 2Identification of a High Affinity Divalent Cation Binding Site near the Entrance of the NMDA Receptor ChannelNeuron, Vol. 16, No. 4Differential effects of lectins on recombinant glutamate receptorsEuropean Journal of Pharmacology: Molecular Pharmacology, Vol. 291, No. 3Neurotransmitters: NMDA receptors: do glia hold the key?Current Biology, Vol. 5, No. 8Mechanosensitivity of NMDA receptors in cultured mouse central neuronsNeuron, Vol. 13, No. 3Glutamate receptor updateCurrent Opinion in Neurobiology, Vol. 4, No. 3 More from this issue > Volume 74Issue 3July 1994Pages 723-760 Copyright & PermissionsCopyright © 1994 the American Physiological Societyhttps://doi.org/10.1152/physrev.1994.74.3.723PubMed8036251History Published online 1 July 1994 Published in print 1 July 1994 Metrics
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