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Involvement of ApoE E4 and H63D in Sporadic Alzheimer's Disease in a Folate-Supplemented Ontario Population

2008; IOS Press; Volume: 14; Issue: 1 Linguagem: Inglês

10.3233/jad-2008-14107

1875-8908

Maire E. Percy, Sharon Moalem, Ángeles García, Martin J. Somerville, Mark Hicks, David Andrews, Azar Azad, Peter Schwarz, Reza Beheshti Zavareh, Rivka Birkan, Clara M. Choo, Vinca Chow, Sandeep Dhaliwal, Victoria Duda, Anthony L. Kupferschmidt, K.W. Lam, Deborah Lightman, Karolina Machalek, Wanna Mar, Frank Nguyen, Piotr J. Rytwinski, Erin Svara, Maithy Tran, Lisa Yeung, Katherine Zanibbi, Rebecca Zener, Melissa Ziraldo, Morris Freedman,

Hemoglobinopathies and Related Disorders

Dysregulation of iron homeostasis is implicated in Alzheimer's disease (AD). In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C