Produção Nacional
Revisado por pares
Diversity of plasmids and transmission of high-levelmupirocin mupA resistance gene in Staphylococcus haemolyticus
2010; Oxford University Press; Volume: 61; Issue: 2 Linguagem: Inglês
10.1111/j.1574-695x.2010.00756.x
ISSN1574-695X
AutoresNatalia Ferreira, Ricardo Pinto Schuenck, Kátia Regina Netto dos Santos, Maria do Carmo de Freire Bastos, Márcia Giambiagi-deMarval,
Tópico(s)Bacterial Identification and Susceptibility Testing
ResumoThe coagulase-negative staphylococci are known for their ability to acquire resistance genes, which limits the choice of therapeutic options for the treatment of infections caused by these microorganisms. In this study, the diversity of high-level mupirocin resistance plasmids (Mup(R) ) was investigated in four strains of Staphylococcus haemolyticus belonging to different pulsed-field gel electrophoresis (PFGE) types or subtypes, isolated in a Brazilian hospital. These strains harbor the mupA gene in large plasmids. In addition, the presence of IS257 sequences flanking the mupA gene was also shown. Two isolates belonging to two different PFGE types exhibited a similar polymorphism for a fragment of the mupA gene and the closest proximal flanking copies of the IS257, suggesting horizontal transmission of S. haemolyticus mupirocin resistance plasmids in the environment and a role of this species as a reservoir of the mupA gene.
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