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Term pregnancy and live birth subsequent to immediate uterine transfer of sperm microinjected oocyte in a natural cycle

2015; Informa; Volume: 31; Issue: 8 Linguagem: Inglês

10.3109/09513590.2015.1031105

1473-0766

Cesare Aragona, Antonella Linari, Giulietta Micara, Daniela Tranquilli, Agnese Maria Lourdes Gambaro, Maria Salomè Bezerra Espinola,

Assisted Reproductive Technology and Twin Pregnancy

It has been reported that it is possible to achieve a pregnancy after immediate uterine transfer of oocyte and sperm, before fertilization and cleavage were known to have occurred; there is an enormous amount of work about the optimal timing of embryo transfer, with no conclusive evidence of a gold standard satisfying patient age, endometrial receptivity, hormonal levels and embryological parameters. We hereby report a case of one 35-year-old nulligravid woman with longstanding tubal factor infertility and 3 previous failed ICSI cycles, treated with ICSI and immediate transfer of the oocyte microinjected with a spermatozoon in a natural cycle. A single oocyte was retrieved, injected with a spermatozoon and transferred 40 min after injection, resulting in an uneventful pregnancy and delivery of a healthy female infant weighing 3320 g at 40 weeks’ estimated gestational age. This case, certainly novel, should be interpreted with caution. Whether confirmed for efficacy and safeness in appropriate controlled clinical trials, our present observation could offer a simple, practical and cost-effective approach in ART programs in selected patients.