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Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense

2015; Elsevier BV; Volume: 126; Issue: 17 Linguagem: Inglês

10.1182/blood-2015-04-639849

1528-0020

Joni M. Prasad, Oleg V. Gorkun, Harini Raghu, Sherry Thornton, Eric S. Mullins, Joseph S. Palumbo, Ya-Ping Ko, Magnus Höök, Tovo David, Shaun R. Coughlin, Jay L. Degen, Matthew J. Flick,

Blood Coagulation and Thrombosis Mechanisms

Key Points Mutation of the fibrinogen Aα chain in mice to selectively eliminate thrombin cleavage prevents fibrin polymer formation in vivo. Fibrin polymer formation drives antimicrobial function and supports host survival following S aureus peritoneal infection.