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BIBTEX RIS

Obesity, Intrapancreatic Fatty Infiltration, and Pancreatic Cancer

2015; American Association for Cancer Research; Volume: 21; Issue: 15 Linguagem: Inglês

10.1158/1078-0432.ccr-15-0718

ISSN

1557-3265

Autores

Hua Wang, Anirban Maitra, Huamin Wang,

Tópico(s)

Cancer, Lipids, and Metabolism

Resumo

Obesity and intrapancreatic fatty infiltration are associated with increased risk of pancreatic cancer and its precursor lesions. The interplay among obesity, inflammation, and oncogenic Kras signaling promotes pancreatic tumorigenesis. Targeting the interaction between obesity-associated inflammation and Kras signaling may provide new strategies for prevention and therapy of pancreatic cancer.

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