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Neurotoxic in vivo models of Parkinson’s disease

2010; Elsevier BV; Linguagem: Inglês

10.1016/s0079-6123(10)84002-6

1875-7855

Jason R. Cannon, J. Timothy Greenamyre,

biodegradable polymer synthesis and properties

Animal models have been invaluable to Parkinson's disease (PD) research. Of these, neurotoxin models have historically been the most widely utilized. The goal of this chapter is to give a brief historical description of classic PD models and then to identify the most recent important advances in modeling human PD in animals. Indeed, significant advances in modeling additional features of PD and expansion to new species have occurred in both older and newer models. The roles these new advances in modeling may have in future PD research are examined in this chapter.